Details

Autor(en) / Beteiligte

• Amiano, Nicolás O
• Pellegrini, Joaquín M
• Morelli, María P
• Martinena, Camila
• Rolandelli, Agustín
• Castello, Florencia A
• Casco, Nicolás
• Ciallella, Lorena M
• de Casado, Graciela C
• Armitano, Rita
• Stupka, Juan
• Gallego, Claudio
• Palmero, Domingo J
• García, Verónica E
• Tateosian, Nancy L

Titel

Circulating Monocyte-Like Myeloid Derived Suppressor Cells and CD16 Positive Monocytes Correlate With Immunological Responsiveness of Tuberculosis Patients

Ist Teil von

• Frontiers in cellular and infection microbiology, 2022-03, Vol.12, p.841741-841741

Ort / Verlag

Switzerland: Frontiers Media S.A

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Alterations of myeloid cell populations have been reported in patients with tuberculosis (TB). In this work, we studied the relationship between myeloid-derived suppressor cells (MDSC) and monocytes subsets with the immunological responsiveness of TB patients. Individuals with active TB were classified as low responders (LR-TB) or high responders (HR-TB) according to their T cell responses against a cell lysate of ( -Ag). Thus, LR-TB, individuals with severe disease, display a weaker immune response to compare to HR-TB, subjects with strong immunity against the bacteria. We observed that LR-TB presented higher percentages of CD16 positive monocytes as compared to HR-TB and healthy donors. Moreover, monocyte-like (M-MDSC) and polymorphonuclear-like (PMN-MDSC) MDSC were increased in patients and the proportion of M-MDSC inversely correlated with IFN-γ levels released after -Ag stimulation in HR-TB. We also found that LR-TB displayed the highest percentages of circulating M-MDSC. These results demonstrate that CD16 positive monocytes and M-MDSC frequencies could be used as another immunological classification parameter. Interestingly, in LR-TB, frequencies of CD16 positive monocytes and M-MDSC were restored after only three weeks of anti-TB treatment. Together, our findings show a link between the immunological status of TB patients and the levels of different circulating myeloid cell populations.