Details

Autor(en) / Beteiligte

• Gordon, Tal
• Zaquin, Tal
• Kowarsky, Mark Alec
• Voskoboynik, Yotam
• Hendin, Noam
• Wurtzel, Omri
• Caicci, Federico
• Manni, Lucia
• Voskoboynik, Ayelet
• Shenkar, Noa

Titel

Stemness Activity Underlying Whole Brain Regeneration in a Basal Chordate

Ist Teil von

• Cells (Basel, Switzerland), 2022-11, Vol.11 (23), p.3727

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Understanding how neurons regenerate following injury remains a central challenge in regenerative medicine. Adult mammals have a very limited ability to regenerate new neurons in the central nervous system (CNS). In contrast, the basal chordate can regenerate its entire CNS within seven days of complete removal. Transcriptome sequencing, cellular labeling, and proliferation in vivo essays revealed that CNS regeneration is mediated by a newly formed neural progeny and the activation of neurodevelopmental pathways that are associated with enhanced stem-cell activity. Analyzing the expression of 239 activated pathways enabled a quantitative understanding of gene-set enrichment patterns at key regeneration stages. The molecular and cellular mechanisms controlling the regenerative ability that this study reveals can be used to develop innovative approaches to enhancing neurogenesis in closely-related chordate species, including humans.