Details

Autor(en) / Beteiligte

• Willgerodt, Nina
• Bührer, Christoph
• Rossi, Rainer
• Kühn, Thomas
• Rüdiger, Mario
• Avenarius, Stefan
• Böttger, Ralf
• Olbertz, Dirk M.
• Proquitte, Hans
• Bittrich, Hans-Jörg
• Haase, Roland
• Fröhlich, Matthias
• Höhne, Sybille
• Thome, Ulrich H.

Titel

Similar adverse outcome rates with high or low oxygen saturation targets in an area with low background mortality

Ist Teil von

• Frontiers in pediatrics, 2023-10, Vol.11, p.1235877-1235877

Ort / Verlag

Frontiers Media S.A

Erscheinungsjahr

2023

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Background Randomized controlled trials have indicated reduced mortality rates in very preterm infants assigned to high compared to low oxygen saturation (SpO 2 ) target levels, accompanied by higher rates of retinopathy of prematurity and bronchopulmonary dysplasia. However, the benefit-to-harm ratio may depend on the local background mortality risk. We therefore aimed to quantify the risk–benefit ratios of different SpO 2 target ranges in 10 tertiary newborn intensive care units (NICUs) in East Germany. Methods In a retrospective multicenter study, 1,399 infants born between 2008 and 2012 at a gestational age between 24 0/7 and 27 6/7 weeks and with a birthweight below 1,250 g were grouped according to the hospital's target SpO 2 range [high oxygen saturation group (HOSG) above 90%], low oxygen saturation group (LOSG) below 90%] and the compliance of units with their target SpO 2 range. The association between neonatal morbidities, neurodevelopmental outcomes, selected treatment strategies, and target SpO 2 ranges was calculated using chi-squared and Mann Whitney U tests. Results Nine of the ten participating NICUs met their SpO 2 target ranges. Five units were considered as HOSG, and five units were considered as LOSG. Necrotizing enterocolitis and intraventricular hemorrhage grade ≥ 2 occurred significantly more frequently in the HOSG than in the LOSG (8.4% vs. 5.1%, p = 0.02; and 26.6% vs. 17.7%, p < 0.001). No significant differences in the mortality rate and the rate of retinopathy of prematurity were found. Conclusion In our patient population, a lower SpO 2 target range was not associated with increased safety risks in extremely preterm infants. We cannot be sure that our outcome differences are associated with differences in oxygen saturations due to the retrospective study design and the differences in site practices.