Details

Autor(en) / Beteiligte

• Nuriel, Tal
• Peng, Katherine Y
• Ashok, Archana
• Dillman, Allissa A
• Figueroa, Helen Y
• Apuzzo, Justin
• Ambat, Jayanth
• Levy, Efrat
• Cookson, Mark R
• Mathews, Paul M
• Duff, Karen E

Titel

The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo

Ist Teil von

• Frontiers in neuroscience, 2017-12, Vol.11, p.702-702

Ort / Verlag

Switzerland: Frontiers Research Foundation

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Freely accessible e-journals

Beschreibungen/Notizen

• Possession of the ε4 allele of apolipoprotein E ( ) is the major genetic risk factor for late-onset Alzheimer's disease (AD). Although numerous hypotheses have been proposed, the precise cause of this increased AD risk is not yet known. In order to gain a more comprehensive understanding of 's role in AD, we performed RNA-sequencing on an AD-vulnerable vs. an AD-resistant brain region from aged APOE targeted replacement mice. This transcriptomics analysis revealed a significant enrichment of genes involved in endosomal-lysosomal processing, suggesting an -specific endosomal-lysosomal pathway dysregulation in the brains of mice. Further analysis revealed clear differences in the morphology of endosomal-lysosomal compartments, including an age-dependent increase in the number and size of early endosomes in mice. These findings directly link the genotype to endosomal-lysosomal dysregulation in an , AD pathology-free setting, which may play a causative role in the increased incidence of AD among carriers.