Details

Autor(en) / Beteiligte

• Clairman, Hayyah
• Dover, Saunya
• Tomlinson, George
• Beebe, Dean
• Cameron, Bonnie
• Laxer, Ronald M
• Levy, Deborah
• Narang, Indra
• Paetkau, Susan
• Schneider, Rayfel
• Spiegel, Lynn
• Stephens, Samantha
• Stinson, Jennifer
• Tse, Shirley
• Weiss, Shelly
• Whitney, Kristi
• Feldman, Brian M

Titel

Lengthening sleep reduces pain in childhood arthritis: a crossover randomised controlled trial

Ist Teil von

• Rheumatic & musculoskeletal diseases open, 2023-10, Vol.9 (4), p.e003352

Ort / Verlag

London: EULAR

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• ObjectivesJuvenile idiopathic arthritis (JIA) is a common chronic childhood disease and chronic pain is a debilitating feature. A strong link has been shown between poor sleep and pain in JIA. However, the causal direction is unknown. This study’s aim was to determine if, in adolescents with JIA, a recommended healthful sleep duration leads to reductions in pain when compared with the restricted sleep (RS) duration that is commonly seen.MethodsPatients with JIA (12–18 years old; pain score of ≥1 on a visual analogue scale) participated in a randomised, crossover sleep manipulation protocol. The 3-week protocol comprised a baseline week (BL), a week with healthy sleep duration (HSD; 9.5 hours in bed/night) and a RS week (RS; 6.5 hours in bed/night). After BL, participants were randomly assigned to either HSD or RS, and then crossed over to the other condition. Pain was self-assessed using the iCanCope with Pain app. We used Bayesian hierarchical models to estimate the effect of sleep duration on pain.ResultsParticipants (n=31; mean age=15.0±1.8 years) averaged 1.4 (95% credible interval (CrI) 1.2–1.6) more hours of sleep per night during HSD relative to RS. Compared with RS, HSD resulted in a favourable effect on pain scores (OR 0.61, 95% CrI 0.39–0.95).ConclusionIt is possible to have adolescents with childhood arthritis get a healthier sleep duration, and this longer sleep results in reduced pain. These findings complement prior correlational studies and confirm a causal relationship between reduced sleep duration and increased pain.Trial registration numberNCT04133662.