Details

Autor(en) / Beteiligte

• Groen, Albert K
• Nieuwdorp, Max

Titel

An evaluation of the therapeutic potential of fecal microbiota transplantation to treat infectious and metabolic diseases

Ist Teil von

• EMBO molecular medicine, 2017-01, Vol.9 (1), p.1-3

Ort / Verlag

England: John Wiley & Sons, Inc

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Fecal microbiota transplantation (FMT) has had a long history in medicine for treating a number of human diseases. As early as during the 4th century BC, FMT was used in China to treat patients with food poisoning and diarrhea. Over time, the method became obsolete, particularly after the realization that hygiene plays an important role in preventing infectious diseases. It was not until the late 1950s that FMT garnered interest again when the first reports about its use to treat fulminant enterocolitis appeared in the scientific literature. However, FMT's breakthrough as the method of choice for the treatment of persistent Clostridium difficile infection (CDI) came only after a double‐blind randomized trial (van Nood et al, ), which demonstrated 94% efficacy of FMT compared with 31% after conservative treatment with vancomycin. Fecal microbiota transplantation (FMT) has had a long history in medicine for treating a number of human diseases. While it seems to work for persistent Clostridium difficile infections, results are variable for other disorders. A. Groen and M. Nieuwdorp's commentary sheds light on this issue.