Details

Autor(en) / Beteiligte

• Jensen, Benjamin A H
• Holm, Jacob B
• Larsen, Ida S
• von Burg, Nicole
• Derer, Stefanie
• Sonne, Si B
• Pærregaard, Simone I
• Damgaard, Mads V
• Indrelid, Stine A
• Rivollier, Aymeric
• Agrinier, Anne-Laure
• Sulek, Karolina
• Arnoldussen, Yke J
• Fjære, Even
• Marette, André
• Angell, Inga L
• Rudi, Knut
• Treebak, Jonas T
• Madsen, Lise
• Åkesson, Caroline Piercey
• Agace, William
• Sina, Christian
• Kleiveland, Charlotte R
• Kristiansen, Karsten
• Lea, Tor E

Titel

Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3 + RORγt + IL-17 + Tregs and improve metabolism

Ist Teil von

• Nature communications, 2021-02, Vol.12 (1), p.1093-19, Article 1093

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Interactions between host and gut microbial communities are modulated by diets and play pivotal roles in immunological homeostasis and health. We show that exchanging the protein source in a high fat, high sugar, westernized diet from casein to whole-cell lysates of the non-commensal bacterium Methylococcus capsulatus Bath is sufficient to reverse western diet-induced changes in the gut microbiota to a state resembling that of lean, low fat diet-fed mice, both under mild thermal stress (T22 °C) and at thermoneutrality (T30 °C). Concomitant with microbiota changes, mice fed the Methylococcus-based western diet exhibit improved glucose regulation, reduced body and liver fat, and diminished hepatic immune infiltration. Intake of the Methylococcu-based diet markedly boosts Parabacteroides abundances in a manner depending on adaptive immunity, and upregulates triple positive (Foxp3 RORγt IL-17 ) regulatory T cells in the small and large intestine. Collectively, these data point to the potential for leveraging the use of McB lysates to improve immunometabolic homeostasis.