Details

Autor(en) / Beteiligte

• Carstens, Julienne L
• Correa de Sampaio, Pedro
• Yang, Dalu
• Barua, Souptik
• Wang, Huamin
• Rao, Arvind
• Allison, James P
• LeBleu, Valerie S
• Kalluri, Raghu

Titel

Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer

Ist Teil von

• Nature communications, 2017-04, Vol.8 (1), p.15095-15095, Article 15095

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2017

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The exact nature and dynamics of pancreatic ductal adenocarcinoma (PDAC) immune composition remains largely unknown. Desmoplasia is suggested to polarize PDAC immunity. Therefore, a comprehensive evaluation of the composition and distribution of desmoplastic elements and T-cell infiltration is necessary to delineate their roles. Here we develop a novel computational imaging technology for the simultaneous evaluation of eight distinct markers, allowing for spatial analysis of distinct populations within the same section. We report a heterogeneous population of infiltrating T lymphocytes. Spatial distribution of cytotoxic T cells in proximity to cancer cells correlates with increased overall patient survival. Collagen-I and αSMA fibroblasts do not correlate with paucity in T-cell accumulation, suggesting that PDAC desmoplasia may not be a simple physical barrier. Further exploration of this technology may improve our understanding of how specific stromal composition could impact T-cell activity, with potential impact on the optimization of immune-modulatory therapies.