Details

Autor(en) / Beteiligte

• Minatoguchi, Shun
• Saito, Shoji
• Furuhashi, Kazuhiro
• Sawa, Yuriko
• Okazaki, Masaki
• Shimamura, Yuko
• Kaihan, Ahmad Baseer
• Hashimoto, Yusaku
• Yasuda, Yoshinari
• Hara, Akitoshi
• Mizutani, Yasuyuki
• Ando, Ryota
• Kato, Noritoshi
• Ishimoto, Takuji
• Tsuboi, Naotake
• Esaki, Nobutoshi
• Matsuyama, Makoto
• Shiraki, Yukihiro
• Kobayashi, Hiroki
• Asai, Naoya
• Enomoto, Atsushi
• Maruyama, Shoichi

Titel

A novel renal perivascular mesenchymal cell subset gives rise to fibroblasts distinct from classic myofibroblasts

Ist Teil von

• Scientific reports, 2022-03, Vol.12 (1), p.5389-5389, Article 5389

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Perivascular mesenchymal cells (PMCs), which include pericytes, give rise to myofibroblasts that contribute to chronic kidney disease progression. Several PMC markers have been identified; however, PMC heterogeneity and functions are not fully understood. Here, we describe a novel subset of renal PMCs that express Meflin, a glycosylphosphatidylinositol-anchored protein that was recently identified as a marker of fibroblasts essential for cardiac tissue repair. Tracing the lineage of Meflin PMCs, which are found in perivascular and periglomerular areas and exhibit renin-producing potential, showed that they detach from the vasculature and proliferate under disease conditions. Although the contribution of Meflin PMCs to conventional α-SMA myofibroblasts is low, they give rise to fibroblasts with heterogeneous α-SMA expression patterns. Genetic ablation of Meflin PMCs in a renal fibrosis mouse model revealed their essential role in collagen production. Consistent with this, human biopsy samples showed that progressive renal diseases exhibit high Meflin expression. Furthermore, Meflin overexpression in kidney fibroblasts promoted bone morphogenetic protein 7 signals and suppressed myofibroblastic differentiation, implicating the roles of Meflin in suppressing tissue fibrosis. These findings demonstrate that Meflin marks a PMC subset that is functionally distinct from classic pericytes and myofibroblasts, highlighting the importance of elucidating PMC heterogeneity.