Nutrients, 2018-11, Vol.10 (11), p.1808
2018
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- Autor(en) / Beteiligte
- Titel
- Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane Induced Dystrophy and Hijacks Polyunsaturated Fatty Acid Metabolism toward β-Oxidation
- Ist Teil von
- Nutrients, 2018-11, Vol.10 (11), p.1808
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2018
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Chemotherapy-induced alopecia (CIA) is a common side effect of conventional chemotherapy and represents a major problem in clinical oncology. Even months after the end of chemotherapy, many cancer patients complain of hair loss, a condition that is psychologically difficult to manage. CIA disturbs social and sexual interactions and causes anxiety and depression. Synthetic drugs protecting from CIA and endowed with hair growth stimulatory properties are prescribed with caution by oncologists. Hormones, growth factors, morphogens could unwontedly protect tumour cells or induce cancer cell proliferation and are thus considered incompatible with many chemotherapy regimens. Nutraceuticals, on the contrary, have been shown to be safe and effective treatment options for hair loss. We here show that polyphenols from cv Annurca are endowed with hair growth promoting activity and can be considered a safe alternative to avoid CIA. In vitro, Annurca Apple Polyphenolic Extract (AAE) protects murine Hair Follicles (HF) from taxanes induced dystrophy. Moreover, in virtue of its mechanism of action, AAE is herein proven to be compatible with chemotherapy regimens. AAE forces HFs to produce ATP using mitochondrial β-oxidation, reducing Pentose Phosphate Pathway (PPP) rate and nucleotides production. As consequence, DNA replication and mitosis are not stimulated, while a pool of free amino acids usually involved in catabolic reactions are spared for keratin production. Moreover, measuring the effect exerted on Poly Unsaturated Fatty Acid (PUFA) metabolism, we prove that AAE promotes hair-growth by increasing the intracellular levels of Prostaglandins F2α (PGF2α) and by hijacking PUFA catabolites toward β-oxidation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2072-6643eISSN: 2072-6643DOI: 10.3390/nu10111808Titel-ID: cdi_doaj_primary_oai_doaj_org_article_626f8dabf27c4fe6a0390d8fbcab250c
- Format
- –
- Schlagworte
- Adenosine triphosphate, Administration, Topical, Alopecia, Alopecia - chemically induced, Alopecia - prevention & control, Animals, Antineoplastic Agents - adverse effects, Apoptosis, apple polyphenols, Bridged-Ring Compounds - adverse effects, Cancer therapies, Catabolites, Cell growth, Cell proliferation, Chemotherapy, chemotherapy induced alopecia, Clinical trials, Dietary Supplements, Dinoprost - analysis, DNA biosynthesis, Dystrophy, Fatty acids, Fatty Acids, Unsaturated - metabolism, Follicles, Food, Functional foods & nutraceuticals, Growth factors, Hair, Hair Follicle - drug effects, Hair Follicle - metabolism, Hair loss, Hormones, Intracellular levels, Keratin, Keratins - biosynthesis, Lipids, Male, Malus - chemistry, Mass spectrometry, Mental depression, Metabolism, Metabolites, Mice, Mice, Inbred C57BL, Mitochondria, Mitosis, Nucleotides, nutraceuticals, Oncology, Oxidation, Oxidation-Reduction, Pentose, Pentose phosphate pathway, Pharmacy, Plant Extracts - administration & dosage, Polyphenols, Polyphenols - administration & dosage, Prostaglandins, Prostaglandins F2, PUFA, Scientific imaging, Side effects, Taxanes, Taxoids - adverse effects, Tumors