Details

Autor(en) / Beteiligte

• Fonseca, Aldilane Gonçalves
• Ribeiro Dantas, Luzia Leiros Sena Fernandes
• Fernandes, Júlia Morais
• Zucolotto, Silvana Maria
• Lima, Adley Antoninni Neves
• Soares, Luiz Alberto Lira
• Rocha, Hugo Alexandre Oliveira
• Lemos, Telma Maria Araújo Moura
• Ali, Shakir
• Shakir Ali

Titel

In Vivo and In Vitro Toxicity Evaluation of Hydroethanolic Extract of Kalanchoe brasiliensis (Crassulaceae) Leaves

Ist Teil von

• Journal of toxicology, 2018-01, Vol.2018, p.6849765-8

Ort / Verlag

Egypt: Hindawi

Erscheinungsjahr

2018

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The species Kalanchoe brasiliensis, known as “Saião,” has anti-inflammatory, antimicrobial, and antihistamine activities. It also has the quercetin and kaempferol flavonoids, which exert their therapeutic activities. With extensive popular use besides the defined therapeutical properties, the study of possible side effects is indispensable. The objective of this study is to evaluate the toxicity in vitro and in vivo from the hydroethanolic extract of the leaves of K. brasiliensis. The action of the extract (concentrations from 0.1 to 1000 uL/100 uL) in normal and tumor cells was evaluated using the MTT method. Acute toxicity and subchronic toxicity were evaluated in mice with doses of 250 to 1000 mg/kg orally, following recognized protocols. The in vitro results indicated cytotoxic activity for 3T3 cell line (normal) and 786-0 (kidney carcinoma), showing the activity to be concentration-dependent, reaching 92.23% cell inhibition. In vivo, the extract showed no significant toxicity; only liver changes related to acute toxicity and some signs of liver damage, combining biochemical and histological data. In general, the extract showed low or no toxicity, introducing itself as safe for use with promising therapeutic potential.