International journal of molecular sciences, 2021-08, Vol.22 (17), p.9125
2021
Details
- Autor(en) / Beteiligte
- Titel
- Enhancement of Immune Checkpoint Inhibitor-Mediated Anti-Cancer Immunity by Intranasal Treatment of Ecklonia cava Fucoidan against Metastatic Lung Cancer
- Ist Teil von
- International journal of molecular sciences, 2021-08, Vol.22 (17), p.9125
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Although fucoidan, a well-studied seaweed-extracted polysaccharide, has shown immune stimulatory effects that elicit anticancer immunity, mucosal adjuvant effects via intranasal administration have not been studied. In this study, the effect of -extracted fucoidan (ECF) on the induction of anti-cancer immunity in the lung was examined by intranasal administration. In C57BL/6 and BALB/c mice, intranasal administration of ECF promoted the activation of dendritic cells (DCs), natural killer (NK) cells, and T cells in the mediastinal lymph node (mLN). The ECF-induced NK and T cell activation was mediated by DCs. In addition, intranasal injection with ECF enhanced the anti-PD-L1 antibody-mediated anti-cancer activities against B16 melanoma and CT-26 carcinoma tumor growth in the lungs, which were required cytotoxic T lymphocytes and NK cells. Thus, these data demonstrated that ECF functioned as a mucosal adjuvant that enhanced the immunotherapeutic effect of immune checkpoint inhibitors against metastatic lung cancer.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1422-0067, 1661-6596eISSN: 1422-0067DOI: 10.3390/ijms22179125Titel-ID: cdi_doaj_primary_oai_doaj_org_article_4f28e9e6f9c44dc5b2fa029f9385c267
- Format
- –
- Schlagworte
- Adjuvants, Immunologic - administration & dosage, Adjuvants, Immunologic - pharmacology, Adjuvants, Immunologic - therapeutic use, Administration, Intranasal, Animals, anti-cancer, anti-PD-L1 antibody, Antigens, Cancer therapies, Cell activation, Cell Line, Tumor, Chromatography, Cytotoxicity, Dendritic cells, Dendritic Cells - drug effects, Dendritic Cells - immunology, Drug Combinations, Ecklonia cava, Ecklonia cava fucoidan, Female, Fucoidan, Immune checkpoint inhibitors, Immune Checkpoint Inhibitors - administration & dosage, Immune Checkpoint Inhibitors - therapeutic use, Immunity, Immunotherapy, Infectious diseases, Intranasal administration, Killer Cells, Natural - drug effects, Killer Cells, Natural - immunology, Laminaria - chemistry, Ligands, Lung cancer, Lung Neoplasms - drug therapy, Lung Neoplasms - pathology, Lymph nodes, Lymphocyte Activation, Lymphocytes, Lymphocytes T, Melanoma, Metastases, Metastasis, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Molecular weight, Mucosa, mucosal adjuvant, Mucosal immunity, Natural killer cells, Neoplasm Metastasis, PD-L1 protein, Plant Extracts, Polysaccharides, Polysaccharides - administration & dosage, Polysaccharides - pharmacology, Polysaccharides - therapeutic use, Seaweeds, Tumor necrosis factor-TNF, Vaccines