Details
- Autor(en) / Beteiligte
- Titel
- The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem cell niche function
- Ist Teil von
- eLife, 2014-09, Vol.3, p.e03696-e03696
- Ort / Verlag
- England: eLife Sciences Publications Ltd
- Erscheinungsjahr
- 2014
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Mesenchymal stem cells (MSCs) and osteolineage cells contribute to the hematopoietic stem cell (HSC) niche in the bone marrow of long bones. However, their developmental relationships remain unclear. In this study, we demonstrate that different MSC populations in the developing marrow of long bones have distinct functions. Proliferative mesoderm-derived nestin(-) MSCs participate in fetal skeletogenesis and lose MSC activity soon after birth. In contrast, quiescent neural crest-derived nestin(+) cells preserve MSC activity, but do not generate fetal chondrocytes. Instead, they differentiate into HSC niche-forming MSCs, helping to establish the HSC niche by secreting Cxcl12. Perineural migration of these cells to the bone marrow requires the ErbB3 receptor. The neonatal Nestin-GFP(+) Pdgfrα(-) cell population also contains Schwann cell precursors, but does not comprise mature Schwann cells. Thus, in the developing bone marrow HSC niche-forming MSCs share a common origin with sympathetic peripheral neurons and glial cells, and ontogenically distinct MSCs have non-overlapping functions in endochondrogenesis and HSC niche formation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2050-084XeISSN: 2050-084XDOI: 10.7554/eLife.03696Titel-ID: cdi_doaj_primary_oai_doaj_org_article_406410c3528a499e915d0c27ebb848ba
- Format
- –
- Schlagworte
- Animals, Bone marrow, Bone Marrow Cells - cytology, Cell cycle, Cell Lineage, Cell Movement, Cell Proliferation, Chemokine CXCL12 - biosynthesis, Chondrocytes, Chondrogenesis, CXCL12 protein, Datasets, Developmental Biology and Stem Cells, ErbB-3 protein, Fetus - cytology, Fetuses, Glial cells, Green Fluorescent Proteins - metabolism, hematopoietic stem cell, Hematopoietic stem cells, Hematopoietic Stem Cells - cytology, Long bone, mesenchymal stem cell, Mesenchymal stem cells, Mesenchymal Stromal Cells - cytology, Mesenchymal Stromal Cells - metabolism, Mesenchyme, Mesoderm, Mice, Inbred C57BL, Neonates, Nestin, Nestin - metabolism, Neural crest, Neural Crest - cytology, Neural stem cells, Neuronal-glial interactions, Population, Principal Component Analysis, Principal components analysis, Proteins, Receptor, Platelet-Derived Growth Factor alpha - metabolism, Schwann cells, Schwann Cells - cytology, Schwann Cells - metabolism, Skeletogenesis, Smooth muscle, Stem Cell Niche, Stem cells