Nature communications, 2020-08, Vol.11 (1), p.4261-4261, Article 4261
2020
Details
- Autor(en) / Beteiligte
- Titel
- ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells
- Ist Teil von
- Nature communications, 2020-08, Vol.11 (1), p.4261-4261, Article 4261
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Metastasis, the spread of malignant cells from a primary tumour to distant sites, causes 90% of cancer-related deaths. The integrin ITGB3 has been previously described to play an essential role in breast cancer metastasis, but the precise mechanisms remain undefined. We have now uncovered essential and thus far unknown roles of ITGB3 in vesicle uptake. The functional requirement for ITGB3 derives from its interactions with heparan sulfate proteoglycans (HSPGs) and the process of integrin endocytosis, allowing the capture of extracellular vesicles and their endocytosis-mediated internalization. Key for the function of ITGB3 is the interaction and activation of focal adhesion kinase (FAK), which is required for endocytosis of these vesicles. Thus, ITGB3 has a central role in intracellular communication via extracellular vesicles, proposed to be critical for cancer metastasis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2041-1723eISSN: 2041-1723DOI: 10.1038/s41467-020-18081-9Titel-ID: cdi_doaj_primary_oai_doaj_org_article_338f9cbec70b4e3c819e7803bef5e010
- Format
- –
- Schlagworte
- Animals, Breast cancer, Breast Neoplasms - metabolism, Breast Neoplasms - pathology, Cell Communication - physiology, Cell interactions, Cell Line, Tumor, Cell signaling, Culture Media, Conditioned, Endocytosis, Extracellular vesicles, Extracellular Vesicles - metabolism, Female, Focal adhesion kinase, Focal Adhesion Kinase 1 - metabolism, Heparan sulfate, Heparan sulfate proteoglycans, Heparan Sulfate Proteoglycans - metabolism, Heterografts, Humans, Integrin beta3 - metabolism, Internalization, Intracellular signalling, Kinases, Lung Neoplasms - metabolism, Lung Neoplasms - pathology, Lung Neoplasms - secondary, MCF-7 Cells, Metastases, Metastasis, Mice, Mice, Nude, Models, Biological, Neoplasm Metastasis - pathology, Neoplasm Transplantation, Proteoglycans, Sulfates, Tumors, Vesicles