Biomedicine & pharmacotherapy, 2022-11, Vol.155, p.113753-113753, Article 113753
2022
Details
- Autor(en) / Beteiligte
- Titel
- The role of lncRNA just proximal to XIST (JPX) in human disease phenotypes and RNA methylation: The novel biomarker and therapeutic target potential
- Ist Teil von
- Biomedicine & pharmacotherapy, 2022-11, Vol.155, p.113753-113753, Article 113753
- Ort / Verlag
- Elsevier Masson SAS
- Erscheinungsjahr
- 2022
- Link zum Volltext
- Quelle
- EZB Electronic Journals Library
- Beschreibungen/Notizen
- Increasing evidence suggests that long non-coding RNAs (lncRNAs) are closely related to the initialization and development of human diseases. lncRNA just proximal to XIST (JPX), as a newly identified lncRNA, has been reported to be aberrantly expressed and associated with pathophysiological traits in numerous diseases, particularly cancers. More importantly, JPX has been proven to play important roles in various biological functions, including cell proliferation, migration, invasion, apoptosis, chemoresistance, and differentiation. In addition, we discuss the diverse molecular mechanisms and correlation with RNA methylation of JPX in several cancers. In this Review, we summarize current studies on JPX's roles in diseases and its potential application as a biomarker for both diagnoses and prognoses and a therapeutic target in human diseases. [Display omitted] •LncRNA JPX expression was dysregulated in various human diseases.•Summarize latest research of clinical characteristics and mechanisms of LncRNA JPX.•LncRNA JPX could be a novel biomarker and therapeutic target potential in human diseases.