Details

Autor(en) / Beteiligte

• Ong, Samantha Kah Ling
• Shanmugam, Muthu K
• Fan, Lu
• Fraser, Sarah E
• Arfuso, Frank
• Ahn, Kwang Seok
• Sethi, Gautam
• Bishayee, Anupam

Titel

Focus on Formononetin: Anticancer Potential and Molecular Targets

Ist Teil von

• Cancers, 2019-05, Vol.11 (5), p.611

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2019

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Formononetin, an isoflavone, is extracted from various medicinal plants and herbs, including the red clover ( and Chinese medicinal plant Formononetin's antioxidant and neuroprotective effects underscore its therapeutic use against Alzheimer's disease. Formononetin has been under intense investigation for the past decade as strong evidence on promoting apoptosis and against proliferation suggests for its use as an anticancer agent against diverse cancers. These anticancer properties are observed in multiple cancer cell models, including breast, colorectal, and prostate cancer. Formononetin also attenuates metastasis and tumor growth in various in vivo studies. The beneficial effects exuded by formononetin can be attributed to its antiproliferative and cell cycle arrest inducing properties. Formononetin regulates various transcription factors and growth-factor-mediated oncogenic pathways, consequently alleviating the possible causes of chronic inflammation that are linked to cancer survival of neoplastic cells and their resistance against chemotherapy. As such, this review summarizes and critically analyzes current evidence on the potential of formononetin for therapy of various malignancies with special emphasis on molecular targets.