Details

Autor(en) / Beteiligte

• Roy-Vallejo, Emilia
• Cardeñoso, Laura
• Triguero-Martínez, Ana
• Chicot Llano, Marta
• Zurita, Nelly
• Ávalos, Elena
• Barrios, Ana
• Hernando, Julia
• Ortiz, Javier
• Rodríguez-García, Sebastián C.
• Ciudad Sañudo, Marianela
• Marcos, Celeste
• García Castillo, Elena
• Fontán García-Rodrigo, Leticia
• González, Begoña
• Méndez, Rosa
• Iturrate, Isabel
• Sanz-García, Ancor
• Villa, Almudena
• Sánchez-Azofra, Ana
• Quicios, Begoña
• Arribas, David
• Álvarez Rodríguez, Jesús
• Patiño, Pablo
• Trigueros, Marina
• Uriarte, Miren
• Martín-Ramírez, Alexandra
• Arévalo Román, Cristina
• Galván-Román, José María
• García-Vicuña, Rosario
• Ancochea, Julio
• Muñoz-Calleja, Cecilia
• Fernández-Ruiz, Elena
• de la Cámara, Rafael
• Suárez Fernández, Carmen
• González-Álvaro, Isidoro
• Rodríguez-Serrano, Diego A.

Titel

SARS-CoV-2 Viremia Precedes an IL6 Response in Severe COVID-19 Patients: Results of a Longitudinal Prospective Cohort

Ist Teil von

• Frontiers in medicine, 2022-06, Vol.9, p.855639-855639

Ort / Verlag

Frontiers Media S.A

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Background Interleukin 6 (IL6) levels and SARS-CoV-2 viremia have been correlated with COVID-19 severity. The association over time between them has not been assessed in a prospective cohort. Our aim was to evaluate the relationship between SARS-CoV-2 viremia and time evolution of IL6 levels in a COVID-19 prospective cohort. Methods Secondary analysis from a prospective cohort including COVID-19 hospitalized patients from Hospital Universitario La Princesa between November 2020 and January 2021. Serial plasma samples were collected from admission until discharge. Viral load was quantified by Real-Time Polymerase Chain Reaction and IL6 levels with an enzyme immunoassay. To represent the evolution over time of both variables we used the graphic command twoway of Stata. Results A total of 57 patients were recruited, with median age of 63 years (IQR [53–81]), 61.4% male and 68.4% Caucasian. The peak of viremia appeared shortly after symptom onset in patients with persistent viremia (more than 1 sample with > 1.3 log10 copies/ml) and also in those with at least one IL6 > 30 pg/ml, followed by a progressive increase in IL6 around 10 days later. Persistent viremia in the first week of hospitalization was associated with higher levels of IL6. Both IL6 and SARS-CoV-2 viral load were higher in males, with a quicker increase with age. Conclusion In those patients with worse outcomes, an early peak of SARS-CoV-2 viral load precedes an increase in IL6 levels. Monitoring SARS-CoV-2 viral load during the first week after symptom onset may be helpful to predict disease severity in COVID-19 patients.