Details

Autor(en) / Beteiligte

• Batool, Zahra
• Muhammad, Gulzar
• Iqbal, Muhammad Mudassir
• Aslam, Muhammad Shahbaz
• Raza, Muhammad Arshad
• Sajjad, Noreen
• Abdullah, Muhammad
• Akhtar, Naeem
• Syed, Asad
• Elgorban, Abdallah M
• Al-Rejaie, Salim S
• Shafiq, Zahid

Titel

Hydrogel assisted synthesis of gold nanoparticles with enhanced microbicidal and in vivo wound healing potential

Ist Teil von

• Scientific reports, 2022-04, Vol.12 (1), p.6575-6575, Article 6575

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2022

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The present study reports a hydrogel-based sunlight-assisted synthesis of gold nanoparticles (Au NPs) with enhanced antimicrobial and wound healing potential. The hydrogel extracted from the seeds of Cydonia oblonga was used as a reducing and capping agent to synthesize Au NPs for the first time. The as-synthesized Au NPs were characterized for an average size, shape, surface functionalization, antimicrobial, and wound healing capabilities. The cubic and rectangular-shaped Au NPs with an average edge length of 74 ± 4.57 nm depicted a characteristic surface plasmon resonance band at 560 nm. The hydrogel-based Au NPs inhibited the growth of microorganisms in zones with 12 mm diameter. In-vitro experiments showed that a minimum inhibitory concentration of Au NPs (16 µg/mL) was sufficient to mimic the 95% growth of pathogenic microorganisms in 24 h. In vivo treatment of wounds with Au NPs in murine models revealed a 99% wound closure within 5 days. Quantitative PCR analysis performed to decipher the role of Au NPs in enhanced wound healing showed an increase in the expression levels of NANOG and CD-34 proteins.