Nutrients, 2020-06, Vol.12 (6), p.1669
2020
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Details
- Autor(en) / Beteiligte
- Titel
- Interference on Iodine Uptake and Human Thyroid Function by Perchlorate-Contaminated Water and Food
- Ist Teil von
- Nutrients, 2020-06, Vol.12 (6), p.1669
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2020
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Perchlorate-induced natrium-iodide symporter (NIS) interference is a well-recognized thyroid disrupting mechanism. It is unclear, however, whether a chronic low-dose exposure to perchlorate delivered by food and drinks may cause thyroid dysfunction in the long term. Thus, the aim of this review was to overview and summarize literature results in order to clarify this issue. Authors searched PubMed/MEDLINE, Scopus, Web of Science, institutional websites and Google until April 2020 for relevant information about the fundamental mechanism of the thyroid NIS interference induced by orally consumed perchlorate compounds and its clinical consequences. Food and drinking water should be considered relevant sources of perchlorate. Despite some controversies, cross-sectional studies demonstrated that perchlorate exposure affects thyroid hormone synthesis in infants, adolescents and adults, particularly in the case of underlying thyroid diseases and iodine insufficiency. An exaggerated exposure to perchlorate during pregnancy leads to a worse neurocognitive and behavioral development outcome in infants, regardless of maternal thyroid hormone levels. The effects of a chronic low-dose perchlorate exposure on thyroid homeostasis remain still unclear, leading to concerns especially for highly sensitive patients. Specific studies are needed to clarify this issue, aiming to better define strategies of detection and prevention.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2072-6643eISSN: 2072-6643DOI: 10.3390/nu12061669Titel-ID: cdi_doaj_primary_oai_doaj_org_article_2c39efbce321405790e1668f4809ce1f
- Format
- –
- Schlagworte
- Beverages, Cognition, Cross-sectional studies, drinking and Food, Drinking water, Endocrine disruptors, Exposure, Female, Food, Food Contamination, Homeostasis, Homeostasis - drug effects, Hormones, Humans, Hyperthyroidism, Hypothyroidism, Hypothyroidism - chemically induced, Hypothyroidism - diagnosis, Hypothyroidism - prevention & control, Infants, Iodides, Iodine, Iodine - metabolism, Male, Metabolism, Natrium/Iodide symporter, Perchlorate, Perchlorates - adverse effects, Perchloric acid, Pregnancy, Review, Signal transduction, Sodium - metabolism, Symporters - drug effects, Thyroid diseases, Thyroid Diseases - chemically induced, Thyroid Diseases - diagnosis, Thyroid Diseases - prevention & control, Thyroid Gland - metabolism, Thyroid Hormones - metabolism, Water, Water pollution, Websites