Details

Autor(en) / Beteiligte

• Jamil, Waqas
• Perveen, Shagufta
• Shah, Syed Adnan Ali
• Taha, Muhammad
• Ismail, Nor Hadiani
• Perveen, Shahnaz
• Ambreen, Nida
• Khan, Khalid M
• Choudhary, Muhammad I

Titel

Phenoxyacetohydrazide Schiff bases: β-glucuronidase inhibitors

Ist Teil von

• Molecules (Basel, Switzerland), 2014-06, Vol.19 (7), p.8788-8802

Ort / Verlag

Switzerland: MDPI

Erscheinungsjahr

2014

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Phenoxyacetohydrazide Schiff base analogs 1-28 have been synthesized and their in vitro β-glucouoronidase inhibition potential studied. Compounds 1 (IC50=9.20±0.32 µM), 5 (IC50=9.47±0.16 µM), 7 (IC50=14.7±0.19 µM), 8 (IC50=15.4±1.56 µM), 11 (IC50=19.6±0.62 µM), 12 (IC50=30.7±1.49 µM), 15 (IC50=12.0±0.16 µM), 21 (IC50=13.7±0.40 µM) and 22 (IC50=22.0±0.14 µM) showed promising β-glucuronidase inhibition activity, better than the standard (D-saccharic acid-1,4-lactone, IC50=48.4±1.25 µM).