International journal of molecular sciences, 2017-01, Vol.18 (1), p.168-168
2017
Details
- Autor(en) / Beteiligte
- Titel
- 6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice
- Ist Teil von
- International journal of molecular sciences, 2017-01, Vol.18 (1), p.168-168
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2017
- Link zum Volltext
- Quelle
- EZB Free E-Journals
- Beschreibungen/Notizen
- The anti-diabetic activity of ginger powder ( ) has been recently promoted, with the recommendation to be included as one of the dietary supplements for diabetic patients. However, previous studies presented different results, which may be caused by degradation and metabolic changes of ginger components, gingerols, shogaols and paradols. Therefore, we prepared 10 ginger active components, namely 6-, 8-, 10-paradols, 6-, 8-, 10-shogaols, 6-, 8-, 10-gingerols and zingerone, and evaluated their anti-hyperglycemic activity. Among the tested compounds, 6-paradol and 6-shogaol showed potent activity in stimulating glucose utilization by 3T3-L1 adipocytes and C2C12 myotubes. The effects were attributed to the increase in 5' adenosine monophosphate-activated protein kinase (AMPK) phosphorylation in 3T3-L1 adipocytes. 6-Paradol, the major metabolite of 6-shogaol, was utilized in an in vivo assay and significantly reduced blood glucose, cholesterol and body weight in high-fat diet-fed mice.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1422-0067, 1661-6596eISSN: 1422-0067DOI: 10.3390/ijms18010168Titel-ID: cdi_doaj_primary_oai_doaj_org_article_19d8ee8b76094d999c080c508dd24b78
- Format
- –
- Schlagworte
- 3T3-L1 adipocytes, 3T3-L1 Cells, 6-paradol, Adenosine kinase, Adenosine monophosphate, Adipocytes, Adipocytes - cytology, Adipocytes - drug effects, Adipocytes - metabolism, AMP-Activated Protein Kinases - metabolism, Animals, Blood Glucose - metabolism, Body weight, C2C12 myotubes, Catechols - pharmacology, Cell Line, Cholesterol, Diabetes, Diabetes mellitus, Diabetes Mellitus, Type 2 - blood, Diabetes Mellitus, Type 2 - etiology, Diet, High-Fat - adverse effects, Ginger, Glucose, Glucose - metabolism, Glucose Tolerance Test, Guaiacol - analogs & derivatives, Guaiacol - pharmacology, High fat diet, high-fat diet-fed mice, Humans, Hyperglycemia - blood, Hyperglycemia - etiology, Immunoblotting, Ketones - pharmacology, Kinases, Lipids - biosynthesis, Male, Mice, Mice, Inbred C57BL, Muscle Fibers, Skeletal - cytology, Muscle Fibers, Skeletal - drug effects, Muscle Fibers, Skeletal - metabolism, Myotubes, Phosphorylation, Phosphorylation - drug effects, Phytotherapy - methods, Powder, Protein kinase, Pungent principles, Shogaols, Weight reduction, Zingerone, Zingiber officinale, Zingiber officinale - chemistry