Scientific reports, 2021-02, Vol.11 (1), p.3962-13, Article 3962
2021
Details
- Autor(en) / Beteiligte
- Titel
- Spectrum of mutational signatures in T-cell lymphoma reveals a key role for UV radiation in cutaneous T-cell lymphoma
- Ist Teil von
- Scientific reports, 2021-02, Vol.11 (1), p.3962-13, Article 3962
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- EZB Free E-Journals
- Beschreibungen/Notizen
- T-cell non-Hodgkin's lymphomas develop following transformation of tissue resident T-cells. We performed a meta-analysis of whole exome sequencing data from 403 patients with eight subtypes of T-cell non-Hodgkin's lymphoma to identify mutational signatures and associated recurrent gene mutations. Signature 1, indicative of age-related deamination, was prevalent across all T-cell lymphomas, reflecting the derivation of these malignancies from memory T-cells. Adult T-cell leukemia-lymphoma was specifically associated with signature 17, which was found to correlate with the IRF4 K59R mutation that is exclusive to Adult T-cell leukemia-lymphoma. Signature 7, implicating UV exposure was uniquely identified in cutaneous T-cell lymphoma (CTCL), contributing 52% of the mutational burden in mycosis fungoides and 23% in Sezary syndrome. Importantly this UV signature was observed in CD4 + T-cells isolated from the blood of Sezary syndrome patients suggesting extensive re-circulation of these T-cells through skin and blood. Analysis of non-Hodgkin's T-cell lymphoma cases submitted to the national 100,000 WGS project confirmed that signature 7 was only identified in CTCL strongly implicating UV radiation in the pathogenesis of cutaneous T-cell lymphoma.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2045-2322eISSN: 2045-2322DOI: 10.1038/s41598-021-83352-4Titel-ID: cdi_doaj_primary_oai_doaj_org_article_14f26d51c7e44279991de8475f3bb7bb
- Format
- –
- Schlagworte
- Age, CD4 antigen, CD4-Positive T-Lymphocytes - metabolism, Databases, Genetic, Deamination, Humans, Immunological memory, Interferon regulatory factor 4, Interferon Regulatory Factors, Leukemia, Lymphocytes T, Lymphoma, Lymphoma, T-Cell - etiology, Lymphoma, T-Cell - genetics, Lymphoma, T-Cell - metabolism, Lymphoma, T-Cell - pathology, Lymphoma, T-Cell, Cutaneous - etiology, Lymphoma, T-Cell, Cutaneous - genetics, Lymphoma, T-Cell, Cutaneous - pathology, Memory cells, Mutation, Mutation - genetics, Mycosis, Mycosis fungoides, Non-Hodgkin's lymphoma, Sezary syndrome, Sezary Syndrome - blood, Skin Neoplasms - pathology, T-cell lymphoma, Ultraviolet radiation, Ultraviolet Rays - adverse effects