Nature communications, 2021-01, Vol.12 (1), p.312-14, Article 312
2021
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Carbon nano-onion-mediated dual targeting of P-selectin and P-glycoprotein to overcome cancer drug resistance
- Ist Teil von
- Nature communications, 2021-01, Vol.12 (1), p.312-14, Article 312
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2021
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The transmembrane P-glycoprotein (P-gp) pumps that efflux drugs are a major mechanism of cancer drug resistance. They are also important in protecting normal tissue cells from poisonous xenobiotics and endogenous metabolites. Here, we report a fucoidan-decorated silica-carbon nano-onion (FSCNO) hybrid nanoparticle that targets tumor vasculature to specifically release P-gp inhibitor and anticancer drug into tumor cells. The tumor vasculature targeting capability of the nanoparticle is demonstrated using multiple models. Moreover, we reveal the superior light absorption property of nano-onion in the near infrared region (NIR), which enables triggered drug release from the nanoparticle at a low NIR power. The released inhibitor selectively binds to P-gp pumps and disables their function, which improves the bioavailability of anticancer drug inside the cells. Furthermore, free P-gp inhibitor significantly increases the systemic toxicity of a chemotherapy drug, which can be resolved by delivering them with FSCNO nanoparticles in combination with a short low-power NIR laser irradiation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2041-1723eISSN: 2041-1723DOI: 10.1038/s41467-020-20588-0Titel-ID: cdi_doaj_primary_oai_doaj_org_article_0dcc96fe3e8f47d092bab3e71efd82f3
- Format
- –
- Schlagworte
- Animals, ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism, Bioavailability, Blood vessels, Cancer, Carbon, Carbon - chemistry, Cell Death - drug effects, Cell Line, Tumor, Cell Proliferation - drug effects, Chemotherapy, Doxorubicin - pharmacology, Drug Delivery Systems, Drug resistance, Drug Resistance, Neoplasm - drug effects, Efflux, Electromagnetic absorption, Fucoidan, Glycoproteins, Human Umbilical Vein Endothelial Cells - drug effects, Human Umbilical Vein Endothelial Cells - metabolism, Humans, Inhibitors, Irradiation, Metabolites, Mice, Microfluidics, Nanoparticles, Nanoparticles - chemistry, Nanoparticles - ultrastructure, Near infrared radiation, Neoplasms - blood supply, Neoplasms - drug therapy, P-Glycoprotein, P-selectin, P-Selectin - metabolism, Photothermal Therapy, Polysaccharides - chemistry, Pumps, Silica, Silicon dioxide, Silicon Dioxide - chemistry, Toxicity, Tumor cells, Tumors, Xenobiotics