Details

Autor(en) / Beteiligte

• Rodero, Mathieu P.
• Tesser, Alessandra
• Bartok, Eva
• Rice, Gillian I.
• Della Mina, Erika
• Depp, Marine
• Beitz, Benoit
• Bondet, Vincent
• Cagnard, Nicolas
• Duffy, Darragh
• Dussiot, Michael
• Frémond, Marie-Louise
• Gattorno, Marco
• Guillem, Flavia
• Kitabayashi, Naoki
• Porcheray, Fabrice
• Rieux-Laucat, Frederic
• Seabra, Luis
• Uggenti, Carolina
• Volpi, Stefano
• Zeef, Leo A H.
• Alyanakian, Marie-Alexandra
• Beltrand, Jacques
• Bianco, Anna Monica
• Boddaert, Nathalie
• Brouzes, Chantal
• Candon, Sophie
• Caorsi, Roberta
• Charbit, Marina
• Fabre, Monique
• Faletra, Flavio
• Girard, Muriel
• Harroche, Annie
• Hartmann, Evelyn
• Lasne, Dominique
• Marcuzzi, Annalisa
• Neven, Bénédicte
• Nitschke, Patrick
• Pascreau, Tiffany
• Pastore, Serena
• Picard, Capucine
• Picco, Paolo
• Piscianz, Elisa
• Polak, Michel
• Quartier, Pierre
• Rabant, Marion
• Stocco, Gabriele
• Taddio, Andrea
• Uettwiller, Florence
• Valencic, Erica
• Vozzi, Diego
• Hartmann, Gunther
• Barchet, Winfried
• Hermine, Olivier
• Bader-Meunier, Brigitte
• Tommasini, Alberto
• Crow, Yanick J.

Titel

Type I interferon-mediated autoinflammation due to DNase II deficiency

Ist Teil von

• Nature communications, 2017-12, Vol.8 (1), p.2176-15, Article 2176

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Microbial nucleic acid recognition serves as the major stimulus to an antiviral response, implying a requirement to limit the misrepresentation of self nucleic acids as non-self and the induction of autoinflammation. By systematic screening using a panel of interferon-stimulated genes we identify two siblings and a singleton variably demonstrating severe neonatal anemia, membranoproliferative glomerulonephritis, liver fibrosis, deforming arthropathy and increased anti-DNA antibodies. In both families we identify biallelic mutations in DNASE2 , associated with a loss of DNase II endonuclease activity. We record increased interferon alpha protein levels using digital ELISA, enhanced interferon signaling by RNA-Seq analysis and constitutive upregulation of phosphorylated STAT1 and STAT3 in patient lymphocytes and monocytes. A hematological disease transcriptomic signature and increased numbers of erythroblasts are recorded in patient peripheral blood, suggesting that interferon might have a particular effect on hematopoiesis. These data define a type I interferonopathy due to DNase II deficiency in humans. Nucleic acid sensing is important to ensure that an innate immune response is only mounted against microbial nucleic acid. Here, the authors identify loss-of-function mutations in the DNASE2 gene that cause type I interferon-mediated autoinflammation due to enhanced systemic interferon signaling.