Journal of Nutritional Science and Vitaminology, 2005, Vol.51(5), pp.361-368
2005
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- Autor(en) / Beteiligte
- Titel
- Peroxisome proliferation in liver of rats fed oxidized frying oil
- Ist Teil von
- Journal of Nutritional Science and Vitaminology, 2005, Vol.51(5), pp.361-368
- Ort / Verlag
- Tokyo: Center for Academic Publications Japan
- Erscheinungsjahr
- 2005
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Oxidized frying oil (OFO) activates peroxisome proliferator-activated receptor a (PPAR alpha) in vitro and in vivo. As most PPAR alpha activators are also peroxisome proliferators (PP), this study was aimed at exploring whether OFO induces peroxisome proliferation in the liver of rats. Four groups of male weanling Sprague-Dawley rats were fed the following diets for 6 wk: a basal diet containing 5 g/100 g fresh soybean oil (LSB), high-fat diets containing 20 g/100 g of fresh soybean oil (HSB as a control), OFO (HO) or fish oil (HF, as a positive control). Hepatomegaly and peroxisome proliferation in the liver of the HO group of rats were higher than those of the HF group. In addition, the acyl-CoA oxidase (ACO) activity, as well as cytochrome P450 4A (CYP4A) protein content in the livers of the HO group were 6 fold those of the HSB group, but were 2.5 fold in those of the HF group. These results indicated that dietary OFO induced typical responses to PPARalpha signaling. Moreover, as a dietary source, the OFO prepared under our frying conditions appears to be a more potent peroxisome proliferator than fish oil.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0301-4800eISSN: 1881-7742DOI: 10.3177/jnsv.51.361Titel-ID: cdi_crossref_primary_10_3177_jnsv_51_361
- Format
- –
- Schlagworte
- ACEITES, ACEITES DE PESCADO, acyl-CoA oxidase, Acyl-CoA Oxidase - genetics, Acyl-CoA Oxidase - metabolism, Animals, Biological and medical sciences, Body Weight, CITOCROMO P450, Cooking, Cytochrome P-450 CYP4A - genetics, Cytochrome P-450 CYP4A - metabolism, CYTOCHROME P450, cytochrome P450 4A, Dietary Fats, Unsaturated - pharmacology, Feeding. Feeding behavior, fish oil, FISH OILS, Fish Oils - pharmacology, FRITURA, FRITURE, FRYING, Fundamental and applied biological sciences. Psychology, Gene Expression, Histocytochemistry, HUILE, HUILE DE POISSON, Lipid Metabolism, Liver - drug effects, Liver - metabolism, Liver - physiology, Liver - ultrastructure, Male, OILS, Oxidation-Reduction, oxidized frying oil, OXIDOREDUCTASES, OXIDORREDUCTASAS, OXYDOREDUCTASE, peroxi some proliferation, Peroxisome Proliferators - pharmacology, Peroxisomes - drug effects, Peroxisomes - physiology, Peroxisomes - ultrastructure, PPAR alpha - metabolism, RAT, RATA, RATS, Rats, Sprague-Dawley, Soybean Oil - pharmacology, Vertebrates: anatomy and physiology, studies on body, several organs or systems