Details
- Autor(en) / Beteiligte
- Titel
- Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis
- Ist Teil von
- Blood, 2009-04, Vol.113 (14), p.3172-3181
- Ort / Verlag
- Washington, DC: Elsevier Inc
- Erscheinungsjahr
- 2009
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Retinoids triggers differentiation of acute promyelocytic leukemia (APL) blasts by transcriptional regulation of myeloid regulatory genes. Using a microarray approach, we have identified a novel retinoid-responsive gene (CXXC5) encoding a nuclear factor, retinoid-inducible nuclear factor (RINF), that contains a CXXC-type zinc-finger motif. RINF expression correlates with retinoid-induced differentiation of leukemic cells and with cytokine-induced myelopoiesis of normal CD34+ progenitors. Furthermore, short hairpin RNA (shRNA) interference suggests for this gene a regulatory function in both normal and tumoral myelopoiesis. Interestingly, RINF localizes to 5q31.3, a small region often deleted in myeloid leukemia (acute myeloid leukemia [AML]/myelodysplasia [MDS]) and suspected to harbor one or several tumor suppressor gene.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0006-4971eISSN: 1528-0020DOI: 10.1182/blood-2008-07-170035Titel-ID: cdi_crossref_primary_10_1182_blood_2008_07_170035
- Format
- –
- Schlagworte
- Amino Acid Sequence, Biological and medical sciences, Carrier Proteins - genetics, Carrier Proteins - physiology, DNA-Binding Proteins, Gene Expression Profiling, Gene Expression Regulation - drug effects, Granulocyte Precursor Cells - drug effects, Granulocyte Precursor Cells - physiology, Hematologic and hematopoietic diseases, Hematologic Neoplasms - genetics, HL-60 Cells, Humans, Intracellular Signaling Peptides and Proteins - genetics, Intracellular Signaling Peptides and Proteins - physiology, K562 Cells, Medical sciences, Models, Biological, Molecular Sequence Data, Myelopoiesis - drug effects, Myelopoiesis - genetics, Oligonucleotide Array Sequence Analysis, Sequence Homology, Amino Acid, Transcription Factors, Tretinoin - pharmacology, Tumor Cells, Cultured