Details

Autor(en) / Beteiligte

• Lader, Alan S
• Smith, Rebecca S
• Phillips, George C
• McNamee, James E
• Abel, Francis L

Titel

Distribution of coronary arterial capacitance in a canine model

Ist Teil von

• Journal of applied physiology (1985), 1998-03, Vol.84 (3), p.954-962

Ort / Verlag

Bethesda, MD: Am Physiological Soc

Erscheinungsjahr

1998

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Department of Physiology, University of South Carolina School of Medicine, Columbia, South Carolina 29208 The capacitative properties of the major left coronary arteries, left main (LM), left anterior descending (LAD), and left circumflex (LCX), were studied in 19 open-chest isolated dog hearts. Capacitance was determined by using ramp perfusion and a left ventricular-to-coronary shunt diastolic decay method; both methods gave similar results, indicating a minimal systolic capacitative component. Increased pericardial pressure (PCP), 25 mmHg, was used to experimentally alter transmural wall pressure. The response to increased PCP was different in the LAD vs. LCX; increasing PCP decreased capacitance in the LCX but increased capacitance in the LAD. This may have been due to the different intramural vs. epicardial volume distribution of these vessels and a decrease in intramural tension during increased PCP. Increased PCP decreased LCX capacitance by ~13%, but no changes in conductance or zero flow pressure intercept occurred in any of the three vessels, i.e., evidence against the waterfall theory of vascular collapse at these levels of PCP. Coronary arterial capacitance was also linearly related to perfusion pressure. coronary blood flow; coronary vascular properties; pericardial pressure; coronary vascular compliance JAP 84(3):954-962 0161-7567/98 $5.00 Copyright © 1998 the American Physiological Society