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GETTING THE MESSAGE ACROSS: The Intracellular Localization of mRNAs in Higher Eukaryotes
Ist Teil von
Annual review of cell and developmental biology, 2001-01, Vol.17 (1), p.569-614
Ort / Verlag
Palo Alto, CA 94303-0139: Annual Reviews
Erscheinungsjahr
2001
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
The intracellular localization of mRNA, a common mechanism for targeting
proteins to specific regions of the cell, probably occurs in most if not all
polarized cell types. Many of the best characterized localized mRNAs are found
in oocytes and early embryos, where they function as localized determinants
that control axis formation and the development of the germline. However, mRNA
localization has also been shown to play an important role in somatic cells,
such as neurons, where it may be involved in learning and memory. mRNAs can be
localized by a variety of mechanisms including local protection from
degradation, diffusion to a localized anchor, and active transport, and we
consider the evidence for each of these processes, before discussing the
cis
-acting elements that direct the localization of specific mRNAs and
the
trans
-acting factors that bind them.