Details

Autor(en) / Beteiligte

• Ferenci, Peter
• Brunner, Harald
• Nachbaur, Karin
• Datz, Christian
• Gschwantler, Michael
• Hofer, Harald
• Stauber, Rudolf
• Hackl, Franz
• Jessner, Wolfgang
• Rosenbeiger, Martha
• Munda-Steindl, Petra
• Hegenbarth, Karin
• Gangl, Alfred
• Vogel, Wolfgang

Titel

Combination of interferon induction therapy and ribavirin in chronic hepatitis C

Ist Teil von

• Hepatology (Baltimore, Md.), 2001-11, Vol.34 (5), p.1006-1011

Ort / Verlag

Philadelphia, PA: Elsevier Inc

Erscheinungsjahr

2001

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The initial clearance of hepatitis C virus (HCV) during interferon-alfa therapy is dose-dependent. Therefore, higher initial interferon doses (induction therapy) may improve treatment results. This concept was tested in a prospective, randomized controlled trial. Previously untreated patients with chronic hepatitis C were randomized to receive 3 different interferon doses during the first 14 weeks of therapy (Group A, n = 130: 10 MU IntronA [AESCA-Schering Plough, Traiskirchen, Austria]/day for 2 weeks, followed by 10 MU/2 days for 12 weeks; Group B, n = 124: 5 MU/day for 14 weeks; Group C, n = 119; 5 MU/2 days for 14 weeks) followed in all by 5 MU/2 days for 24 weeks. Throughout the whole study all patients received 1 to 1.2 g ribavirin/day. On treatment, no differences in viral clearance rates were observed. Sustained response rates were also not different among the groups (A: 48.5%, B and C: 41.3%, intent to treat). When data were analyzed according to genotypes, sustained response was almost twice as high in patients with genotype 1 receiving high-dose interferon induction therapy (A: 44.2%, B: 28.6%, C: 27%, P < .05). In contrast, results were not different in genotype 3a patients (A: 61.3%, B: 75.9%, C: 56.3%; P > .1). These data indicate that high-dose interferon induction therapy may improve the outcome of interferon/ribavirin combination therapy in genotype 1 patients. (HEPATOLOGY 2001;34:1006-1011.)