Details

Autor(en) / Beteiligte

• Sen, Sajal
• Perrin, Mark W
• Sedgwick, Adam C
• Dunsky, Evie Y
• Lynch, Vincent M
• He, Xiao-Peng
• Sessler, Jonathan L
• Arambula, Jonathan F

Titel

Toward multifunctional anticancer therapeutics: post-synthetic carbonate functionalisation of asymmetric Au() bis-N-heterocyclic carbenes

Ist Teil von

• Chemical communications (Cambridge, England), 2020-07, Vol.56 (57), p.7877-788

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• A post-synthetic strategy is reported that allows for functionalisation of Au( i )-bis NHCs via carbonate formation. The scope of this methodology was explored using both aromatic and aliphatic alcohols. As a demonstration of potential utility, the fluorescent Au( i )-bis NHC conjugate 5 was prepared; it was found to have enhanced stability when formulated with bovine serum albumin, localise within the mitochondria of A549 cells and do so without compromising the high cytotoxicity seen for the parent Au( i )-bis NHC system. A post-synthetic strategy is reported that permits functionalization of Au( i )-bis NHCs via carbonate formation and synthesis of a potential multifunctional anticancer therapeutic.