Details

Autor(en) / Beteiligte

• Mizutani, Y.
• Masuoka, S.
• Imoto, M.
• Kawada, M.
• Umezawa, K.

Titel

Induction of Erythroid Differentiation in Leukemic K562 Cells by an S-Adenosylhomocysteine Hydrolase Inhibitor, Aristeromycin

Ist Teil von

• Biochemical and biophysical research communications, 1995-02, Vol.207 (1), p.69-74

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

1995

Link zum Volltext

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• We have isolated an unusual nucleoside, aristeromycin, from the culture filtrate of Actinomycetes as a compound that induces normal morphology in v-abl ts-NIH3T3 cells. Aristeromycin also induced erythroid differentiation in abl-expressing human chronic myelogenous leukaemia K562 cells. It did not affect the amount of Abl or the Abl-associated tyrosine kinase activity in either v-abl ts-NIH3T3 or K562 cells. As a potent inhibitor of S-adenosylhomocysteine hydrolase, aristeromycin inhibited methylation of phosphatidylethanolamine to form phosphatidylcholine in K562 cells. Among aristeromycin analogues, the activity to inhibit S-adenosylhomocysteine hydrolase was paralleled with the induction of erythroid differentiation. Thus, aristeromycin inhibits abl functions indirectly, possibly by inhibiting biological methylations.