UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 21 von 236
Datensatz exportieren als...
BibTeX
Euro I nf: A M ulticenter C omparative O bservational S tudy of A pomorphine and L evodopa I nfusion in P arkinson's D isease
Movement disorders, 2015-04, Vol.30 (4), p.510-516
Martinez‐Martin, Pablo
Reddy, Prashanth
Katzenschlager, Regina
Antonini, Angelo
Todorova, Antoniya
Odin, Per
Henriksen, Tove
Martin, Anne
Calandrella, Daniela
Rizos, Alexandra
Bryndum, Narissah
Glad, Arne
Dafsari, Haidar Salimi
Timmermann, Lars
Ebersbach, Georg
Kramberger, Milica G.
Samuel, Michael
Wenzel, Karoline
Tomantschger, Volker
Storch, Alexander
Reichmann, Heinz
Pirtosek, Zvezdan
Trost, Maja
Svenningsson, Per
Palhagen, Sven
Volkmann, Jens
Chaudhuri, K. Ray
2015
Details
Autor(en) / Beteiligte
Martinez‐Martin, Pablo
Reddy, Prashanth
Katzenschlager, Regina
Antonini, Angelo
Todorova, Antoniya
Odin, Per
Henriksen, Tove
Martin, Anne
Calandrella, Daniela
Rizos, Alexandra
Bryndum, Narissah
Glad, Arne
Dafsari, Haidar Salimi
Timmermann, Lars
Ebersbach, Georg
Kramberger, Milica G.
Samuel, Michael
Wenzel, Karoline
Tomantschger, Volker
Storch, Alexander
Reichmann, Heinz
Pirtosek, Zvezdan
Trost, Maja
Svenningsson, Per
Palhagen, Sven
Volkmann, Jens
Chaudhuri, K. Ray
Titel
Euro I nf: A M ulticenter C omparative O bservational S tudy of A pomorphine and L evodopa I nfusion in P arkinson's D isease
Ist Teil von
Movement disorders, 2015-04, Vol.30 (4), p.510-516
Erscheinungsjahr
2015
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
ABSTRACT Subcutaneous apomorphine infusion (Apo) and intrajejunal levodopa infusion (IJLI) are two treatment options for patients with advanced Parkinson's disease (PD) and refractory motor complications, with varying cost of treatment. There are no multicenter studies comparing the effects of the two strategies. This open‐label, prospective, observational, 6‐month, multicenter study compared 43 patients on Apo (48.8% males, age 62.3 ± 10.6 years; disease duration: 14 ± 4.4 years; median H & Y stage 3; interquartile range [IQR]: 3‐4) and 44 on IJLI (56.8% males, age 62.7 ± 9.1 years; disease duration: 16.1 ± 6.7 years; median H & Y stage 4; IQR, 3‐4). Cohen's effect sizes (≥0.8 considered as large) were “large” with both therapies with respect to total motor, nonmotor, and quality‐of‐life scores. The Non‐Motor Symptoms Scale (NMSS) with Apo showed moderate improvement, whereas sleep/fatigue, gastrointestinal, urinary, and sexual dimensions of the NMSS showed significantly higher improvement with IJLI. Seventy‐five percent on IJLI improved in their quality‐of‐life and nonmotor symptoms (NMS), whereas in the Apo group, a similar proportion improved in quality of life, but 40% in NMS. Adverse effects included peritonitis with IJLI and skin nodules on Apo. Based on this open‐label, nonrandomized, comparative study, we report that, in advanced Parkinson's patients, both IJLI and Apo infusion therapy appear to provide a robust improvement in motor symptoms, motor complications, quality‐of‐life, and some NMS. Controlled, randomized studies are required. © 2014 International Parkinson and Movement Disorder Society
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185
eISSN: 1531-8257
DOI: 10.1002/mds.26067
Titel-ID: cdi_crossref_primary_10_1002_mds_26067
Format
–
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX