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Lipoprotein profile and lipid metabolism of PXB-cells®, human primary hepatocytes from liver-humanized mice: proposal of novel in vitro system for screening anti-lipidemic drugs

Biomedical Research, 2020/02/01, Vol.41(1), pp.33-42

2020

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Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized TK-NOG mouse

Xenobiotica, 2021-01, Vol.51 (1), p.51-60

2021

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Evaluation of the Utility of PXB Chimeric Mice for Predicting Human Liver Partitioning of Hepatic Organic Anion-Transporting Polypeptide Transporter Substrates

Drug metabolism and disposition, 2021-03, Vol.49 (3), p.254-264

2021

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Application of a Novel Mass Spectral Data Acquisition Approach to Lipidomic Analysis of Liver Extracts from Sitaxentan-Treated Liver-Humanized PXB Mice

Journal of proteome research, 2019-11, Vol.18 (11), p.4055-4064

2019

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THU319 - PXB-cells for the study of lipid metabolism: robust and human-specific lipid profile in human hepatocytes freshly isolated from chimeric mice with humanized liver

Journal of hepatology, 2020-08, Vol.73, p.S294-S294

2020

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PXB-cells for the study of lipid metabolism: robust and human-specific lipid profile in human hepatocytes freshly isolated from chimeric mice with humanized liver

Journal of hepatology, 2020-08, Vol.73, p.S294

2020

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Identification of possible biomarker genes for drug-induced liver injury using chimeric PXB-mouse® with highly humanized liver

Toxicology letters, 2015-10, Vol.238 (2), p.S250-S250

2015

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Detection of aflatoxin B1 hepatotoxicity using PXB-cells

Drug metabolism and pharmacokinetics, 2017-01, Vol.32 (1), p.S63-S63

2017

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Differential Effect of Troglitazone on the Human Bile Acid Transporters, MRP2 and BSEP, in the PXB Hepatic Chimeric Mouse

Toxicologic pathology, 2012-12, Vol.40 (8), p.1106-1116

2012

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Total hepatocellular disposition profiling of acetaminophen and major metabolites in sandwich-cultured PXB-cells

Drug metabolism and pharmacokinetics, 2018-01, Vol.33 (1), p.S68-S68

2018

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Prediction of human-specific metabolites of mianserin, cyproheptadine, and carbazeran using chimeric mice with humanized liver (PXB-MICE)

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S58-S58

2019

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Comprehensive hepatocellular disposition profiling of parent compound and its major metabolites in sandwich-cultured PXB-cells by D-PREX

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S53-S54

Kanda, Katsuhiro

2019

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Transcriptome analysis of human liver in chimeric PXB-Mouse® for risk marker identification associated with drug-induced liver injury

Toxicology letters, 2016-09, Vol.258, p.S90-S90

2016

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Mixed poly-brominated/chlorinated biphenyls (PXBs): Widespread food and environmental contaminants

Environment international, 2012-09, Vol.44, p.118-127

2012

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Prediction of human hepatic clearance for cytochrome P450 substrates via a new culture method using the collagen vitrigel membrane chamber and PXB-cells

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S23-S23

2019

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Mixed halogenated dioxins/furans (PXDD/Fs) and biphenyls (PXBs) in food: Occurrence and toxic equivalent exposure using specific relative potencies

Environment international, 2014-12, Vol.73, p.104-110

2014

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Effects of irinotecan on hepatic gene expression in chimeric PXB-mouse® with highly humanized liver

Toxicology letters, 2014-09, Vol.229, p.S235-S235

2014

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Identification of microRNA as possible risk marker for drug-induced liver injury using chimeric PXB-Mouse® with highly humanized liver

Toxicology letters, 2016-09, Vol.258, p.S77-S78

2016

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In vitro and in vivo induction of cytochrome P450 by coplanar polychlorinated/brominated biphenyls (Co-PXBs) providing high TEQ in mother’s milk in Japan

Toxicology (Amsterdam), 2014-10, Vol.324, p.68-75

2014

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Changes in hepatic gene expression induced by various statin formulations in chimeric PXB-Mouse® with highly humanized liver

Toxicology letters, 2013-08, Vol.221, p.S194-S194

2013

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Occurrence of co-planar polybrominated/chlorinated biphenyls (PXBs), polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in breast milk of women from Spain

Chemosphere (Oxford), 2011-04, Vol.83 (6), p.799-805

2011

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Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l‐lactate transport in the hepatocellular carcinoma cell line

Biopharmaceutics & drug disposition, 2022-10, Vol.43 (5), p.183-191

2022

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Global contamination of coplanar polybrominated/chlorinated biphenyls (Co-PXBs) in the market fishes from Japan

Chemosphere (Oxford), 2008-08, Vol.73 (1), p.S31-S38

2008

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Cell-based high-throughput screening for the evaluation of reactive metabolite formation potential

Toxicology in vitro, 2021-08, Vol.74, p.105159, Article 105159

2021

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Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

Critical reviews in toxicology, 2021-05, Vol.51 (5), p.373-394

2021

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Lipoprotein profile and lipid metabolism of PXB-cells®, human primary hepatocytes from liver-humanized mice: proposal of novel in vitro system for screening anti-lipidemic drugs

Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized TK-NOG mouse

Evaluation of the Utility of PXB Chimeric Mice for Predicting Human Liver Partitioning of Hepatic Organic Anion-Transporting Polypeptide Transporter Substrates

Application of a Novel Mass Spectral Data Acquisition Approach to Lipidomic Analysis of Liver Extracts from Sitaxentan-Treated Liver-Humanized PXB Mice

THU319 - PXB-cells for the study of lipid metabolism: robust and human-specific lipid profile in human hepatocytes freshly isolated from chimeric mice with humanized liver

PXB-cells for the study of lipid metabolism: robust and human-specific lipid profile in human hepatocytes freshly isolated from chimeric mice with humanized liver

Identification of possible biomarker genes for drug-induced liver injury using chimeric PXB-mouse® with highly humanized liver

Detection of aflatoxin B1 hepatotoxicity using PXB-cells

Differential Effect of Troglitazone on the Human Bile Acid Transporters, MRP2 and BSEP, in the PXB Hepatic Chimeric Mouse

Total hepatocellular disposition profiling of acetaminophen and major metabolites in sandwich-cultured PXB-cells

Prediction of human-specific metabolites of mianserin, cyproheptadine, and carbazeran using chimeric mice with humanized liver (PXB-MICE)

Comprehensive hepatocellular disposition profiling of parent compound and its major metabolites in sandwich-cultured PXB-cells by D-PREX

Transcriptome analysis of human liver in chimeric PXB-Mouse® for risk marker identification associated with drug-induced liver injury

Mixed poly-brominated/chlorinated biphenyls (PXBs): Widespread food and environmental contaminants

Prediction of human hepatic clearance for cytochrome P450 substrates via a new culture method using the collagen vitrigel membrane chamber and PXB-cells

Mixed halogenated dioxins/furans (PXDD/Fs) and biphenyls (PXBs) in food: Occurrence and toxic equivalent exposure using specific relative potencies

Effects of irinotecan on hepatic gene expression in chimeric PXB-mouse® with highly humanized liver

Identification of microRNA as possible risk marker for drug-induced liver injury using chimeric PXB-Mouse® with highly humanized liver

In vitro and in vivo induction of cytochrome P450 by coplanar polychlorinated/brominated biphenyls (Co-PXBs) providing high TEQ in mother’s milk in Japan

Changes in hepatic gene expression induced by various statin formulations in chimeric PXB-Mouse® with highly humanized liver

Occurrence of co-planar polybrominated/chlorinated biphenyls (PXBs), polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in breast milk of women from Spain

Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l‐lactate transport in the hepatocellular carcinoma cell line

Global contamination of coplanar polybrominated/chlorinated biphenyls (Co-PXBs) in the market fishes from Japan

Cell-based high-throughput screening for the evaluation of reactive metabolite formation potential

Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

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