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New fossils from Jebel Irhoud, Morocco and the pan-African origin of Homo sapiens

Nature (London), 2017-06, Vol.546 (7657), p.289-292

2017

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The age of the hominin fossils from Jebel Irhoud, Morocco, and the origins of the Middle Stone Age

Nature (London), 2017-06, Vol.546 (7657), p.293-296

2017

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Reactive oxygen species-responsive dexamethasone-loaded nanoparticles for targeted treatment of rheumatoid arthritis via suppressing the iRhom2/TNF-α/BAFF signaling pathway

Biomaterials, 2020-02, Vol.232, p.119730-119730, Article 119730

2020

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iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING

Nature immunology, 2016-09, Vol.17 (9), p.1057

2016

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Strategies to Target ADAM17 in Disease: From its Discovery to the iRhom Revolution

Molecules (Basel, Switzerland), 2021-02, Vol.26 (4), p.944

2021

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Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

Science (American Association for the Advancement of Science), 2012-01, Vol.335 (6065), p.225-228

2012

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iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

Science (American Association for the Advancement of Science), 2012-01, Vol.335 (6065), p.229-232

2012

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iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

Proceedings of the National Academy of Sciences - PNAS, 2015-05, Vol.112 (19), p.6080-6085

2015

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iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling

The Journal of clinical investigation, 2018-04, Vol.128 (4), p.1397-1412

2018

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Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE

Cell reports (Cambridge), 2017-10, Vol.21 (3), p.745-757

2017

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iRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I

Cellular and molecular life sciences : CMLS, 2024-12, Vol.81 (1), p.163-163

2024

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Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activity

Cellular and molecular life sciences : CMLS, 2024-12, Vol.81 (1), p.102-102

2024

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Endoplasmic reticulum stress-induced iRhom2 up-regulation promotes macrophage-regulated cardiac inflammation and lipid deposition in high fat diet (HFD)-challenged mice: Intervention of fisetin and metformin

Free radical biology & medicine, 2019-09, Vol.141, p.67-83

2019

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Infrared head pose estimation with multi-scales feature fusion on the IRHP database for human attention recognition

Neurocomputing (Amsterdam), 2020-10, Vol.411, p.510-520

2020

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iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding

Proceedings of the National Academy of Sciences - PNAS, 2013-07, Vol.110 (28), p.11433-11438

2013

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Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling

eLife, 2017-04, Vol.6

2017

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A structural model of the iRhom–ADAM17 sheddase complex reveals functional insights into its trafficking and activity

Cellular and molecular life sciences : CMLS, 2023-05, Vol.80 (5), p.135-135, Article 135

2023

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iRhom2 regulates ERBB signalling to promote KRAS-driven tumour growth of lung cancer cells

Journal of cell science, 2022-09, Vol.135 (17)

2022

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iRHOM2 is a critical pathogenic mediator of inflammatory arthritis

The Journal of clinical investigation, 2013-02, Vol.123 (2), p.928-932

2013

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Substrate‐selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains

The FASEB journal, 2020-04, Vol.34 (4), p.4956-4969

2020

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Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation

EMBO reports, 2013-10, Vol.14 (10), p.884-890

2013

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EGFR stimulation enables IL-6 trans-signalling via iRhom2-dependent ADAM17 activation in mammary epithelial cells

Biochimica et biophysica acta. Molecular cell research, 2023-10, Vol.1870 (7), p.119489-119489, Article 119489

2023

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Analysis of the function of ADAM17 in iRhom2 curly-bare and tylosis with esophageal cancer mutant mice

Journal of cell science, 2023-07, Vol.136 (13)

2023

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Status update on iRhom and ADAM17: It's still complicated

Biochimica et biophysica acta. Molecular cell research, 2019-10, Vol.1866 (10), p.1567-1583

2019

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Characterization of Hidradenitis Suppurativa Phenotypes: A Multidimensional Latent Class Analysis of the National Italian Registry IRHIS

Journal of investigative dermatology, 2021-05, Vol.141 (5), p.1236-1242.e1

2021

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New fossils from Jebel Irhoud, Morocco and the pan-African origin of Homo sapiens

The age of the hominin fossils from Jebel Irhoud, Morocco, and the origins of the Middle Stone Age

Reactive oxygen species-responsive dexamethasone-loaded nanoparticles for targeted treatment of rheumatoid arthritis via suppressing the iRhom2/TNF-α/BAFF signaling pathway

iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING

Strategies to Target ADAM17 in Disease: From its Discovery to the iRhom Revolution

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE

iRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I

Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activity

Endoplasmic reticulum stress-induced iRhom2 up-regulation promotes macrophage-regulated cardiac inflammation and lipid deposition in high fat diet (HFD)-challenged mice: Intervention of fisetin and metformin

Infrared head pose estimation with multi-scales feature fusion on the IRHP database for human attention recognition

iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding

Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling

A structural model of the iRhom–ADAM17 sheddase complex reveals functional insights into its trafficking and activity

iRhom2 regulates ERBB signalling to promote KRAS-driven tumour growth of lung cancer cells

iRHOM2 is a critical pathogenic mediator of inflammatory arthritis

Substrate‐selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation

EGFR stimulation enables IL-6 trans-signalling via iRhom2-dependent ADAM17 activation in mammary epithelial cells

Analysis of the function of ADAM17 in iRhom2 curly-bare and tylosis with esophageal cancer mutant mice

Status update on iRhom and ADAM17: It's still complicated

Characterization of Hidradenitis Suppurativa Phenotypes: A Multidimensional Latent Class Analysis of the National Italian Registry IRHIS

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