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Sarsasapogenin: A steroidal saponin from Asparagus racemosus as multi target directed ligand in Alzheimer’s disease

Steroids, 2020-01, Vol.153, p.108529-108529, Article 108529

2020

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Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway

International journal of molecular sciences, 2016-08, Vol.17 (9), p.1418-1418

2016

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The anti-tumor effect of OP-B on ovarian cancer in vitro and in vivo, and its mechanism: An investigation using network pharmacology-based analysis

Journal of ethnopharmacology, 2022-01, Vol.283, p.114706-114706, Article 114706

2022

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Characterization of spirostanol glycosides and furostanol glycosides from anemarrhenae rhizoma as dual targeted inhibitors of 5-lipoxygenase and Cyclooxygenase-2 by employing a combination of affinity ultrafiltration and HPLC/MS

Phytomedicine (Stuttgart), 2020-10, Vol.77, p.153284-153284, Article 153284

2020

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Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia

Journal of ethnopharmacology, 2018-03, Vol.214, p.29-36

2018

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Total synthesis and cytotoxicity evaluation of the spirostanol saponin gitonin

Organic & biomolecular chemistry, 2024-03, Vol.22 (1), p.281-29

2024

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Spirostanol Saponins from Flowers of Allium Porrum and Related Compounds Indicating Cytotoxic Activity and Affecting Nitric Oxide Production Inhibitory Effect in Peritoneal Macrophages

Molecules (Basel, Switzerland), 2021-10, Vol.26 (21), p.6533

2021

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Synthesis of new sarsasapogenin derivatives with cytotoxicity and apoptosis-inducing activities in human breast cancer MCF-7 cells

European journal of medicinal chemistry, 2017-02, Vol.127, p.62-71

2017

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Spirostane saponins with a rearranged A/B ring system isolated from the rhizomes of Ophiopogon japonicus

Phytochemistry (Oxford), 2022-01, Vol.193, p.112975-112975, Article 112975

2022

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Ophiopogonin D: A new herbal agent against osteoporosis

Bone (New York, N.Y.), 2015-05, Vol.74, p.18-28

2015

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Discovery of Anti-inflammatory Ingredients in Chinese Herbal Formula Kouyanqing Granule based on Relevance Analysis between Chemical Characters and Biological Effects

Scientific reports, 2015-12, Vol.5 (1), p.18080-18080, Article 18080

2015

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Chemistry, Biosynthesis and Pharmacology of Sarsasapogenin: A Potential Natural Steroid Molecule for New Drug Design, Development and Therapy

Molecules (Basel, Switzerland), 2022-03, Vol.27 (6), p.2032

2022

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Synthesis and SAR study of novel sarsasapogenin derivatives as potent neuroprotective agents and NO production inhibitors

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (3), p.662-665

2017

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Ophiopogonin D attenuates doxorubicin-induced autophagic cell death by relieving mitochondrial damage in vitro and in vivo

The Journal of pharmacology and experimental therapeutics, 2015-01, Vol.352 (1), p.166

2015

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Apoptosis and pro-death autophagy induced by a spirostanol saponin isolated from Rohdea chinensis (Baker) N. Tanaka (synonym Tupistra chinensis Baker) on HL-60 cells

Phytomedicine (Stuttgart), 2018-03, Vol.42, p.83-89

2018

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Timosaponin AIII and its metabolite sarsasapogenin ameliorate colitis in mice by inhibiting NF-κB and MAPK activation and restoring Th17/Treg cell balance

International immunopharmacology, 2015-04, Vol.25 (2), p.493-503

2015

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Spirostanol glycosides with hemostatic and antimicrobial activities from Trillium kamtschaticum

Phytochemistry (Oxford), 2016-11, Vol.131, p.165-173

2016

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Steroidal saponins from Paris polyphylla var. yunnanensis

Phytochemistry (Oxford), 2012-09, Vol.81, p.133-143

2012

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Ophiopogonin B induces the autophagy and apoptosis of colon cancer cells by activating JNK/c-Jun signaling pathway

Biomedicine & pharmacotherapy, 2018-12, Vol.108, p.1208-1215

2018

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Ruscogenin suppressed the hepatocellular carcinoma metastasis via PI3K/Akt/mTOR signaling pathway

Biomedicine & pharmacotherapy, 2018-05, Vol.101, p.115-122

2018

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Protective effects of sarsasapogenin against early stage of diabetic nephropathy in rats

Phytotherapy research, 2018-08, Vol.32 (8), p.1574-1582

2018

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Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice

Acta pharmacologica Sinica, 2021-02, Vol.42 (2), p.272-281

2021

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Synthesis and evaluation of 26-amino acid methyl ester substituted sarsasapogenin derivatives as neuroprotective agents for Alzheimer’s disease

Steroids, 2017-09, Vol.125, p.93-106

2017

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Modulation of transporter activity of OATP1B1 and OATP1B3 by the major active components of Radix Ophiopogonis

Xenobiotica, 2019-10, Vol.49 (10), p.1221-1228

2019

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Gracillin Isolated from Reineckia carnea Induces Apoptosis of A549 Cells via the Mitochondrial Pathway

Drug design, development and therapy, 2021-01, Vol.15, p.233-243

2021

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Sarsasapogenin: A steroidal saponin from Asparagus racemosus as multi target directed ligand in Alzheimer’s disease

Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway

The anti-tumor effect of OP-B on ovarian cancer in vitro and in vivo, and its mechanism: An investigation using network pharmacology-based analysis

Characterization of spirostanol glycosides and furostanol glycosides from anemarrhenae rhizoma as dual targeted inhibitors of 5-lipoxygenase and Cyclooxygenase-2 by employing a combination of affinity ultrafiltration and HPLC/MS

Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia

Total synthesis and cytotoxicity evaluation of the spirostanol saponin gitonin

Spirostanol Saponins from Flowers of Allium Porrum and Related Compounds Indicating Cytotoxic Activity and Affecting Nitric Oxide Production Inhibitory Effect in Peritoneal Macrophages

Synthesis of new sarsasapogenin derivatives with cytotoxicity and apoptosis-inducing activities in human breast cancer MCF-7 cells

Spirostane saponins with a rearranged A/B ring system isolated from the rhizomes of Ophiopogon japonicus

Ophiopogonin D: A new herbal agent against osteoporosis

Discovery of Anti-inflammatory Ingredients in Chinese Herbal Formula Kouyanqing Granule based on Relevance Analysis between Chemical Characters and Biological Effects

Chemistry, Biosynthesis and Pharmacology of Sarsasapogenin: A Potential Natural Steroid Molecule for New Drug Design, Development and Therapy

Synthesis and SAR study of novel sarsasapogenin derivatives as potent neuroprotective agents and NO production inhibitors

Ophiopogonin D attenuates doxorubicin-induced autophagic cell death by relieving mitochondrial damage in vitro and in vivo

Apoptosis and pro-death autophagy induced by a spirostanol saponin isolated from Rohdea chinensis (Baker) N. Tanaka (synonym Tupistra chinensis Baker) on HL-60 cells

Timosaponin AIII and its metabolite sarsasapogenin ameliorate colitis in mice by inhibiting NF-κB and MAPK activation and restoring Th17/Treg cell balance

Spirostanol glycosides with hemostatic and antimicrobial activities from Trillium kamtschaticum

Steroidal saponins from Paris polyphylla var. yunnanensis

Ophiopogonin B induces the autophagy and apoptosis of colon cancer cells by activating JNK/c-Jun signaling pathway

Ruscogenin suppressed the hepatocellular carcinoma metastasis via PI3K/Akt/mTOR signaling pathway

Protective effects of sarsasapogenin against early stage of diabetic nephropathy in rats

Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice

Synthesis and evaluation of 26-amino acid methyl ester substituted sarsasapogenin derivatives as neuroprotective agents for Alzheimer’s disease

Modulation of transporter activity of OATP1B1 and OATP1B3 by the major active components of Radix Ophiopogonis

Gracillin Isolated from Reineckia carnea Induces Apoptosis of A549 Cells via the Mitochondrial Pathway

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