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Identification of RSK substrates using an analog-sensitive kinase approach

The Journal of biological chemistry, 2024-03, Vol.300 (3), p.105739-105739, Article 105739

2024

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RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth

Oncogene, 2013-06, Vol.32 (24), p.2917-2926

2013

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Regulation and function of the RSK family of protein kinases

Biochemical journal, 2012-01, Vol.441 (2), p.553-569

2012

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Covalent docking of large libraries for the discovery of chemical probes

Nature chemical biology, 2014-12, Vol.10 (12), p.1066

2014

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mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling

Molecular and Cellular Biology, 2010-02, Vol.30 (4), p.908-921

2010

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The serine/threonine protein kinase, p90 ribosomal s6 kinase, is an important regulator of prostate cancer cell proliferation

Cancer research (Chicago, Ill.), 2005-04, Vol.65 (8), p.3108-3116

2005

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The RSK family of kinases: emerging roles in cellular signalling

Nature reviews. Molecular cell biology, 2008-10, Vol.9 (10), p.747-758

2008

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The mTOR-S6 kinase pathway promotes stress granule assembly

Cell death and differentiation, 2018-11, Vol.25 (10), p.1766-1780

2018

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Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1

Cell metabolism, 2006-06, Vol.3 (6), p.393-402

2006

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RAS―MAPK―MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1

Nature (London), 2013-06, Vol.498 (7454), p.325-331

2013

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Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

Nature communications, 2018-10, Vol.9 (1), p.4344-8, Article 4344

2018

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Inhibition of mitochondrial complex 1 by the S6K1 inhibitor PF-4708671 partly contributes to its glucose metabolic effects in muscle and liver cells

The Journal of biological chemistry, 2019-08, Vol.294 (32), p.12250-12260

2019

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Altered ERK/MAPK signaling in the hippocampus of the mrsk2_KO mouse model of Coffin‐Lowry syndrome

Journal of neurochemistry, 2011-11, Vol.119 (3), p.447-459

2011

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RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer

The Journal of clinical investigation, 2013-06, Vol.123 (6), p.2551-2563

2013

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BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

Biochemical journal, 2007-01, Vol.401 (1), p.29-38

2007

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Discovery, Optimization, and Structure–Activity Relationship Study of Novel and Potent RSK4 Inhibitors as Promising Agents for the Treatment of Esophageal Squamous Cell Carcinoma

Journal of medicinal chemistry, 2021-09, Vol.64 (18), p.13572-13587

2021

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Discovery of a novel dual-target inhibitor against RSK1 and MSK2 to suppress growth of human colon cancer

Oncogene, 2020-10, Vol.39 (43), p.6733-6746

2020

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Negative feedback via RSK modulates Erk‐dependent progression from naïve pluripotency

EMBO reports, 2018-08, Vol.19 (8), p.n/a

2018

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Polycomb Group Protein Displacement and Gene Activation through MSK-Dependent H3K27me3S28 Phosphorylation

Molecular cell, 2010-09, Vol.39 (6), p.886-900

2010

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Development of a RSK Inhibitor as a Novel Therapy for Triple-Negative Breast Cancer

Molecular cancer therapeutics, 2016-11, Vol.15 (11), p.2598-2608

2016

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Dynamic control of RSK complexes by phosphoswitch‐based regulation

The FEBS journal, 2018-01, Vol.285 (1), p.46-71

2018

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p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells

The Journal of clinical investigation, 2010-04, Vol.120 (4), p.1165-1177

2010

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Inhibition of mTOR ameliorates bleomycin-induced pulmonary fibrosis by regulating epithelial-mesenchymal transition

Biochemical and biophysical research communications, 2018-06, Vol.500 (4), p.839-845

2018

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A Crucial Role for p90RSK-Mediated Reduction of ERK5 Transcriptional Activity in Endothelial Dysfunction and Atherosclerosis

Circulation (New York, N.Y.), 2013-01, Vol.127 (4), p.486-499

2013

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Identification of RSK substrates using an analog-sensitive kinase approach

RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth

Regulation and function of the RSK family of protein kinases

Covalent docking of large libraries for the discovery of chemical probes

mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling

The serine/threonine protein kinase, p90 ribosomal s6 kinase, is an important regulator of prostate cancer cell proliferation

The RSK family of kinases: emerging roles in cellular signalling

The mTOR-S6 kinase pathway promotes stress granule assembly

Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1

RAS―MAPK―MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

Inhibition of mitochondrial complex 1 by the S6K1 inhibitor PF-4708671 partly contributes to its glucose metabolic effects in muscle and liver cells

Altered ERK/MAPK signaling in the hippocampus of the mrsk2_KO mouse model of Coffin‐Lowry syndrome

RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer

S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

Discovery, Optimization, and Structure–Activity Relationship Study of Novel and Potent RSK4 Inhibitors as Promising Agents for the Treatment of Esophageal Squamous Cell Carcinoma

Discovery of a novel dual-target inhibitor against RSK1 and MSK2 to suppress growth of human colon cancer

Negative feedback via RSK modulates Erk‐dependent progression from naïve pluripotency

Polycomb Group Protein Displacement and Gene Activation through MSK-Dependent H3K27me3S28 Phosphorylation

Development of a RSK Inhibitor as a Novel Therapy for Triple-Negative Breast Cancer

Dynamic control of RSK complexes by phosphoswitch‐based regulation

p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells

Inhibition of mTOR ameliorates bleomycin-induced pulmonary fibrosis by regulating epithelial-mesenchymal transition

A Crucial Role for p90RSK-Mediated Reduction of ERK5 Transcriptional Activity in Endothelial Dysfunction and Atherosclerosis

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