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Targeting MCL-1 in hematologic malignancies: Rationale and progress

Blood reviews, 2020-11, Vol.44, p.100672-100672, Article 100672

2020

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Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1

Structure (London), 2019-04, Vol.27 (4), p.606-617.e5

2019

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Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy

The Journal of clinical investigation, 2018-01, Vol.128 (1), p.500-516

2018

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The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

Nature (London), 2016-10, Vol.538 (7626), p.477-482

2016

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Molecular docking studies of bioactive compounds from Annona muricata Linn as potential inhibitors for Bcl-2, Bcl-w and Mcl-1 antiapoptotic proteins

Apoptosis (London), 2018, Vol.23 (1), p.27-40

2018

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Prediction of Hot Spots at Myeloid Cell Leukemia-1–Inhibitor Interface Using Energy Estimation and Alanine Scanning Mutagenesis

Biochemistry (Easton), 2018-02, Vol.57 (7), p.1249-1261

2018

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Re-activation of mitochondrial apoptosis inhibits T-cell lymphoma survival and treatment resistance

Leukemia, 2016-07, Vol.30 (7), p.1520-1530

2016

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Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer's disease mouse model

Nature communications, 2020-11, Vol.11 (1), p.5731-5731, Article 5731

2020

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Pathways and mechanisms of venetoclax resistance

Leukemia & lymphoma, 2017-09, Vol.58 (9), p.2026-2039

2017

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Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy

Nature communications, 2017-07, Vol.8 (1), p.16078-16078, Article 16078

2017

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Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors

Nature communications, 2018-01, Vol.9 (1), p.215-12, Article 215

2018

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Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies

The Journal of biological chemistry, 2016-03, Vol.291 (13), p.6689-6695

2016

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Complementarity and redundancy of IL-22-producing innate lymphoid cells

Nature immunology, 2016-02, Vol.17 (2), p.179

2016

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Genetic screens in isogenic mammalian cell lines without single cell cloning

Nature communications, 2020-02, Vol.11 (1), p.752-15, Article 752

2020

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Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death

Molecular biology of the cell, 2016-01, Vol.27 (1), p.20-34

2016

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Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

Blood, 2017-02, Vol.129 (6), p.771-782

2017

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A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo

Molecular cancer therapeutics, 2014-03, Vol.13 (3), p.565-575

2014

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Neutrophils are required for both the sensitization and elicitation phase of contact hypersensitivity

The Journal of experimental medicine, 2015-01, Vol.212 (1), p.15-22

2015

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Therapeutics targeting Bcl-2 in hematological malignancies

Biochemical journal, 2017-11, Vol.474 (21), p.3643-3657

2017

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Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

Blood, 2018-10, Vol.132 (15), p.1573-1583

2018

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BH3 profiling identifies heterogeneous dependency on Bcl-2 family members in multiple myeloma and predicts sensitivity to BH3 mimetics

Leukemia, 2016-03, Vol.30 (3), p.761-764

2016

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Myeloid cell leukemia-1 is an important apoptotic survival factor in triple-negative breast cancer

Cell death and differentiation, 2015-12, Vol.22 (12), p.2098-2106

2015

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Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown

Proceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (9)

2021

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MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor

Molecular cancer therapeutics, 2015-08, Vol.14 (8), p.1837-1847

2015

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Targeting MCL-1 in hematologic malignancies: Rationale and progress

Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1

Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

Molecular docking studies of bioactive compounds from Annona muricata Linn as potential inhibitors for Bcl-2, Bcl-w and Mcl-1 antiapoptotic proteins

Prediction of Hot Spots at Myeloid Cell Leukemia-1–Inhibitor Interface Using Energy Estimation and Alanine Scanning Mutagenesis

Re-activation of mitochondrial apoptosis inhibits T-cell lymphoma survival and treatment resistance

Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer's disease mouse model

Pathways and mechanisms of venetoclax resistance

Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy

Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors

Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies

Complementarity and redundancy of IL-22-producing innate lymphoid cells

Genetic screens in isogenic mammalian cell lines without single cell cloning

Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo

Neutrophils are required for both the sensitization and elicitation phase of contact hypersensitivity

Therapeutics targeting Bcl-2 in hematological malignancies

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

BH3 profiling identifies heterogeneous dependency on Bcl-2 family members in multiple myeloma and predicts sensitivity to BH3 mimetics

Myeloid cell leukemia-1 is an important apoptotic survival factor in triple-negative breast cancer

Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS -Mutant Non-Small Cell Lung Cancer

Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown

MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor

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