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Deep learning enables rapid identification of potent DDR1 kinase inhibitors

Nature biotechnology, 2019-09, Vol.37 (9), p.1038-1040

2019

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Expression of hepatic drug-metabolizing cytochrome p450 enzymes and their intercorrelations: a meta-analysis

Drug metabolism and disposition, 2014-08, Vol.42 (8), p.1349

2014

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Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans

Drug metabolism and disposition, 2022-05, Vol.50 (5), p.576-590

2022

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Environmentally relevant organophosphate triesters in herring gulls: In vitro biotransformation and kinetics and diester metabolite formation using a hepatic microsomal assay

Toxicology and applied pharmacology, 2016-10, Vol.308, p.59-65

2016

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Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.2940-2955

2022

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Cytochrome P450 2B6 and UDP-Glucuronosyltransferase Enzyme-Mediated Clearance of Ciprofol (HSK3486) in Humans: The Role of Hepatic and Extrahepatic Metabolism

Drug metabolism and disposition, 2024-02, Vol.52 (2), p.106

2024

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Biocatalysis using Thermostable Cytochrome P450 Enzymes in Bacterial Membranes - Comparison of Metabolic Pathways with Human Liver Microsomes and Recombinant Human Enzymes

Drug metabolism and disposition, 2024-02, Vol.52 (3), p.242

2024

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Clearance Prediction Methodology Needs Fundamental Improvement: Trends Common to Rat and Human Hepatocytes/Microsomes and Implications for Experimental Methodology

Drug metabolism and disposition, 2017-11, Vol.45 (11), p.1178-1188

2017

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Does Addition of Protein to Hepatocyte or Microsomal In Vitro Incubations Provide a Useful Improvement in In Vitro-In Vivo Extrapolation Predictability?

Drug metabolism and disposition, 2022-04, Vol.50 (4), p.401-412

2022

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Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom)

Xenobiotica, 2019-11, Vol.49 (11), p.1279-1288

2019

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3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV‑2 Agents

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.2926-2939

2022

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Comparative Proteomics Analysis of Human Liver Microsomes and S9 Fractions

Drug metabolism and disposition, 2020-01, Vol.48 (1), p.31-40

2020

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Development of Azo-Based Fluorescent Probes to Detect Different Levels of Hypoxia

Angewandte Chemie (International ed.), 2013-12, Vol.52 (49), p.13028-13032

International ed. in English, 2013

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Ultralarge Virtual Screening Identifies SARS-CoV‑2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

Journal of the American Chemical Society, 2022-02, Vol.144 (7), p.2905-2920

2022

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Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids

Journal of medicinal chemistry, 2020-01, Vol.63 (1), p.433-439

2020

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CYP1A2-mediated biotransformation of cardioactive 2-thienylidene-3,4-methylenedioxybenzoylhydrazine (LASSBio-294) by rat liver microsomes and human recombinant CYP enzymes

European journal of medicinal chemistry, 2011-01, Vol.46 (1), p.349-355

2011

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The Utility of Mixed Effects Models in the Evaluation of Complex Genomic Traits In Vitro

Drug metabolism and disposition, 2023-11, Vol.51 (11), p.1455

2023

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Large-scale multiplex absolute protein quantification of drug-metabolizing enzymes and transporters in human intestine, liver, and kidney microsomes by SWATH-MS: Comparison with MRM/SRM and HR-MRM/PRM

Proteomics (Weinheim), 2016-08, Vol.16 (15-16), p.2106-2117

2016

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ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth

Nature chemical biology, 2021-08, Vol.17 (8), p.856

2021

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Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors

Journal of medicinal chemistry, 2019-02, Vol.62 (3), p.1138-1166

2019

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Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions

Scientific reports, 2020-11, Vol.10 (1), p.19158, Article 19158

2020

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Apigenin-rivastigmine hybrids as multi-target-directed liagnds for the treatment of Alzheimer’s disease

European journal of medicinal chemistry, 2020-02, Vol.187, p.111958, Article 111958

2020

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Direct and Sequential Bioactivation of Pemigatinib to Reactive Iminium Ion Intermediates Culminates in Mechanism-Based Inactivation of Cytochrome P450 3A

Drug metabolism and disposition, 2022-05, Vol.50 (5), p.529-540

2022

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Influence of metabolism on endocrine activities of bisphenol S

Chemosphere (Oxford), 2016-08, Vol.157, p.152-159

2016

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Prediction of human intestinal first-pass metabolism of 25 CYP3A substrates from in vitro clearance and permeability data

Drug metabolism and disposition, 2010-07, Vol.38 (7), p.1147

2010

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