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Targeting fetal hemoglobin expression to treat β hemoglobinopathies

Expert opinion on therapeutic targets, 2022-04, Vol.26 (4), p.347-359

Steinberg, Martin H

2022

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Sphaerotilus natans hemoglobins have an NADH oxidation activity and promote the yield of limonene in an engineered E. coli strain

International journal of biological macromolecules, 2024-01, Vol.254 (Pt 3), p.128112-128112, Article 128112

2024

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Post-translational transformation of methionine to aspartate is catalyzed by heme iron and driven by peroxide: a novel subunit-specific mechanism in hemoglobin

The Journal of biological chemistry, 2014-08, Vol.289 (32), p.22342-22357

2014

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Hydroxyurea improves nitric oxide bioavailability in humanized sickle cell mice

American journal of physiology. Regulatory, integrative and comparative physiology, 2021-05, Vol.320 (5), p.R630-R640

2021

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Replacement of the Distal Histidine Reveals a Noncanonical Heme Binding Site in a 2‑on‑2 Hemoglobin

Biochemistry (Easton), 2018-10, Vol.57 (40), p.5785-5796

2018

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Design, Synthesis, and Evaluation of Allosteric Effectors for Hemoglobin

Accounts of chemical research, 2023-06, Vol.56 (11), p.1279-1286

2023

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Glycation rate of haemoglobins S, C, D, E, J and G, and analytical interference on the measurement of HbA1c with affinity chromatography and capillary electrophoresis

Clinical chemistry and laboratory medicine, 2015-08, Vol.53 (9), p.e207

2015

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A unified model of human hemoglobin switching through single-cell genome editing

Nature communications, 2021-08, Vol.12 (1), p.4991-4991, Article 4991

2021

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Association between Inflammation and Biological Variation in Hemoglobin A1c in U.S. Nondiabetic Adults

The journal of clinical endocrinology and metabolism, 2015-06, Vol.100 (6), p.2364-2371

2015

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Mechanism of Human Apohemoglobin Unfolding

Biochemistry (Easton), 2017-03, Vol.56 (10), p.1444-1459

2017

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Differential Effects of Dapagliflozin on Cardiovascular Risk Factors at Varying Degrees of Renal Function

Clinical journal of the American Society of Nephrology, 2017-05, Vol.12 (5), p.751-759

2017

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Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease

The Journal of pharmacology and experimental therapeutics, 2022-03, Vol.380 (3), p.210

2022

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Gene Duplication and the Evolution of Hemoglobin Isoform Differentiation in Birds

The Journal of biological chemistry, 2012-11, Vol.287 (45), p.37647-37658

2012

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Overexpression of Shinorhizobium meliloti flavohemoglobin improves cell growth and fatty acid biosynthesis in oleaginous fungus Mucor circinelloides

Biotechnology letters, 2022-04, Vol.44 (4), p.595-604

2022

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Analysis of Minor Hemoglobins by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

Clinical chemistry (Baltimore, Md.), 2005-06, Vol.51 (6), p.989-996

2005

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Role of Nitric Oxide Carried by Hemoglobin in Cardiovascular Physiology: Developments on a Three-Gas Respiratory Cycle

Circulation research, 2020-01, Vol.126 (1), p.129-158

2020

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Hemoglobin Bohr Effects: Atomic Origin of the Histidine Residue Contributions

Biochemistry (Easton), 2013-11, Vol.52 (47), p.8539-8555

2013

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Heterogeneity between Two α Subunits of α 2 β 2 Human Hemoglobin and O 2 Binding Properties: Raman, 1 H Nuclear Magnetic Resonance, and Terahertz Spectra

Biochemistry (Easton), 2017-11, Vol.56 (46), p.6125-6136

2017

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High-throughput assessment of hemoglobin polymer in single red blood cells from sickle cell patients under controlled oxygen tension

Proceedings of the National Academy of Sciences - PNAS, 2019-12, Vol.116 (50), p.25236-25242

2019

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A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition

Nature medicine, 2016-09, Vol.22 (9), p.987-990

2016

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Hydroxylamine Reduction to Ammonium by Plant and Cyanobacterial Hemoglobins

Biochemistry (Easton), 2011-12, Vol.50 (50), p.10829-10835

2011

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The oral ferroportin inhibitor vamifeport improves hemodynamics in a mouse model of sickle cell disease

Blood, 2022-08, Vol.140 (7), p.769-781

2022

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New developments in anti‐sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo?

British journal of haematology, 2016-10, Vol.175 (1), p.24-30

2016

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Comparison of the oxidative reactivity of recombinant fetal and adult human hemoglobin: implications for the design of hemoglobin-based oxygen carriers

Bioscience reports, 2018-08, Vol.38 (4)

2018

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Transcription factor competition at the γ-globin promoters controls hemoglobin switching

Nature genetics, 2021-04, Vol.53 (4), p.511-520

2021

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Targeting fetal hemoglobin expression to treat β hemoglobinopathies

Sphaerotilus natans hemoglobins have an NADH oxidation activity and promote the yield of limonene in an engineered E. coli strain

Post-translational transformation of methionine to aspartate is catalyzed by heme iron and driven by peroxide: a novel subunit-specific mechanism in hemoglobin

Hydroxyurea improves nitric oxide bioavailability in humanized sickle cell mice

Replacement of the Distal Histidine Reveals a Noncanonical Heme Binding Site in a 2‑on‑2 Hemoglobin

Design, Synthesis, and Evaluation of Allosteric Effectors for Hemoglobin

Glycation rate of haemoglobins S, C, D, E, J and G, and analytical interference on the measurement of HbA1c with affinity chromatography and capillary electrophoresis

A unified model of human hemoglobin switching through single-cell genome editing

Association between Inflammation and Biological Variation in Hemoglobin A1c in U.S. Nondiabetic Adults

Mechanism of Human Apohemoglobin Unfolding

Differential Effects of Dapagliflozin on Cardiovascular Risk Factors at Varying Degrees of Renal Function

Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease

Gene Duplication and the Evolution of Hemoglobin Isoform Differentiation in Birds

Overexpression of Shinorhizobium meliloti flavohemoglobin improves cell growth and fatty acid biosynthesis in oleaginous fungus Mucor circinelloides

Analysis of Minor Hemoglobins by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

Role of Nitric Oxide Carried by Hemoglobin in Cardiovascular Physiology: Developments on a Three-Gas Respiratory Cycle

Hemoglobin Bohr Effects: Atomic Origin of the Histidine Residue Contributions

Heterogeneity between Two α Subunits of α 2 β 2 Human Hemoglobin and O 2 Binding Properties: Raman, 1 H Nuclear Magnetic Resonance, and Terahertz Spectra

High-throughput assessment of hemoglobin polymer in single red blood cells from sickle cell patients under controlled oxygen tension

A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition

Hydroxylamine Reduction to Ammonium by Plant and Cyanobacterial Hemoglobins

The oral ferroportin inhibitor vamifeport improves hemodynamics in a mouse model of sickle cell disease

New developments in anti‐sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo?

Comparison of the oxidative reactivity of recombinant fetal and adult human hemoglobin: implications for the design of hemoglobin-based oxygen carriers

Transcription factor competition at the γ-globin promoters controls hemoglobin switching

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