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Use of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 Enzymes

Drug metabolism and disposition, 2016-08, Vol.44 (8), p.1217-1228

2016

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Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite

Drug metabolism and disposition, 2010-01, Vol.38 (1), p.92

2010

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Use of Phenoxyaniline Analogues To Generate Biochemical Insights into the Interactio n of Polybrominated Diphenyl Ether with CYP2B Enzymes

Biochemistry (Easton), 2018-02, Vol.57 (5), p.817-826

2018

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Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

Drug metabolism and disposition, 2009-10, Vol.37 (10), p.2087

2009

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Bacterial Oxidases of the Cytochrome bd Family: Redox Enzymes of Unique Structure, Function, and Utility As Drug Targets

Antioxidants & redox signaling, 2021-06, Vol.34 (16), p.1280

2021

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Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes

PloS one, 2015-07, Vol.10 (7), p.e0132992

2015

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Heterologous expression of high-activity cytochrome P450 in mammalian cells

Scientific reports, 2020-08, Vol.10 (1), p.14193, Article 14193

2020

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Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450

International journal of molecular sciences, 2018-12, Vol.19 (12), p.3914

2018

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Evaluation of Mutual Drug–Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling Method

Basic & clinical pharmacology & toxicology, 2016-09, Vol.119 (3), p.284-290

2016

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Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P‐Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What?

Clinical pharmacology and therapeutics, 2018-12, Vol.104 (6), p.1249-1259

2018

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Respiratory complexes III and IV can each bind two molecules of cytochrome c at low ionic strength

FEBS letters, 2015-02, Vol.589 (4), p.476-483

2015

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Differential expression of cytochrome P450 enzymes in normal and tumor tissues from childhood rhabdomyosarcoma

PloS one, 2014-04, Vol.9 (4), p.e93261-e93261

2014

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Structure of a bacterial cell surface decaheme electron conduit

Proceedings of the National Academy of Sciences - PNAS, 2011-06, Vol.108 (23), p.9384-9389

2011

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Understanding a substrate's product regioselectivity in a family of enzymes: a case study of acetaminophen binding in cytochrome P450s

PloS one, 2014-02, Vol.9 (2), p.e87058-e87058

2014

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The Potential for Pharmacokinetic Interactions Between Cannabis Products and Conventional Medications

Journal of clinical psychopharmacology, 2019-09, Vol.39 (5), p.462

2019

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In Silico Structural, Functional, and Phylogenetic Analysis of Cytochrome (CYPD) Protein Family

BioMed research international, 2021, Vol.2021, p.5574789-13

2021

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Cytochrome P450 Structure, Function and Clinical Significance: A Review

Current drug targets, 2018-01, Vol.19 (1), p.38

2018

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Pogostone inhibits the activity of CYP3A4, 2C9, and 2E1 in vitro

Pharmaceutical biology, 2021-01, Vol.59 (1), p.530-534

2021

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Synthesis, biological evaluation and docking studies of trans‐stilbene methylthio derivatives as cytochromes P450 family 1 inhibitors

Chemical biology & drug design, 2017-12, Vol.90 (6), p.1226-1236

2017

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Physiologically based pharmacokinetic modeling to predict drug-drug interactions involving inhibitory metabolite: a case study of amiodarone

Drug metabolism and disposition, 2015-02, Vol.43 (2), p.182-189

2015

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Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors

Journal of medicinal chemistry, 2017-08, Vol.60 (15), p.6678-6692

2017

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Regio‐ and Stereoselective Steroid Hydroxylation at C7 by Cytochrome P450 Monooxygenase Mutants

Angewandte Chemie (International ed.), 2020-07, Vol.59 (30), p.12499-12505

International ed. in English, 2020

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Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics

Nature communications, 2021-03, Vol.12 (1), p.1621-1621, Article 1621

2021

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Impact of CYP1A2, CYP2C19, and CYP2D6 genotype- and phenoconversion-predicted enzyme activity on clozapine exposure and symptom severity

The pharmacogenomics journal, 2020-04, Vol.20 (2), p.192-201

2020

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Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones

The New phytologist, 2016-04, Vol.210 (2), p.525-534

2016

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Use of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 Enzymes

Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite

Use of Phenoxyaniline Analogues To Generate Biochemical Insights into the Interactio n of Polybrominated Diphenyl Ether with CYP2B Enzymes

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

Bacterial Oxidases of the Cytochrome bd Family: Redox Enzymes of Unique Structure, Function, and Utility As Drug Targets

Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes

Heterologous expression of high-activity cytochrome P450 in mammalian cells

Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450

Evaluation of Mutual Drug–Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling Method

Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P‐Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What?

Respiratory complexes III and IV can each bind two molecules of cytochrome c at low ionic strength

Differential expression of cytochrome P450 enzymes in normal and tumor tissues from childhood rhabdomyosarcoma

Structure of a bacterial cell surface decaheme electron conduit

Understanding a substrate's product regioselectivity in a family of enzymes: a case study of acetaminophen binding in cytochrome P450s

The Potential for Pharmacokinetic Interactions Between Cannabis Products and Conventional Medications

In Silico Structural, Functional, and Phylogenetic Analysis of Cytochrome (CYPD) Protein Family

Cytochrome P450 Structure, Function and Clinical Significance: A Review

Pogostone inhibits the activity of CYP3A4, 2C9, and 2E1 in vitro

Synthesis, biological evaluation and docking studies of trans‐stilbene methylthio derivatives as cytochromes P450 family 1 inhibitors

Physiologically based pharmacokinetic modeling to predict drug-drug interactions involving inhibitory metabolite: a case study of amiodarone

Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors

Regio‐ and Stereoselective Steroid Hydroxylation at C7 by Cytochrome P450 Monooxygenase Mutants

Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics

Impact of CYP1A2, CYP2C19, and CYP2D6 genotype- and phenoconversion-predicted enzyme activity on clozapine exposure and symptom severity

Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones

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