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Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2

Nature communications, 2021-06, Vol.12 (1), p.3356-3356, Article 3356

2021

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p21 produces a bioactive secretome that places stressed cells under immunosurveillance

Science (American Association for the Advancement of Science), 2021-10, Vol.374 (6567), p.eabb3420-eabb3420

2021

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Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo

The Journal of clinical investigation, 2008-01, Vol.118 (1), p.217-228

2008

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Cell cycle regulation: p53-p21-RB signaling

Cell death and differentiation, 2022-05, Vol.29 (5), p.946-960

Engeland, Kurt

2022

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Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2

Nucleic acids research, 2016-04, Vol.44 (6), p.2846

2016

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Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

Aging cell, 2020-03, Vol.19 (3), p.e13094-n/a

2020

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Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2‐independent mechanism

Aging cell, 2017-06, Vol.16 (3), p.564-574

2017

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Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo

The European respiratory journal, 2017-08, Vol.50 (2), p.1602367-1602367

2017

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SP1-induced upregulation of the long noncoding RNA TINCR regulates cell proliferation and apoptosis by affecting KLF2 mRNA stability in gastric cancer

Oncogene, 2015-11, Vol.34 (45), p.5648-5661

2015

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Valproate, in Combination with Pemetrexed and Cisplatin, Provides Additional Efficacy to the Treatment of Malignant Mesothelioma

Clinical cancer research, 2009-04, Vol.15 (8), p.2818-2828

2009

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Absence of cyclin-dependent kinase inhibitor p27 or p18 increases efficiency of iPSC generation without induction of iPSC genomic instability

Cell death & disease, 2019-03, Vol.10 (4), p.271-271, Article 271

2019

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The NUCKS1-SKP2-p21/p27 axis controls S phase entry

Nature communications, 2021-11, Vol.12 (1), p.6959-14, Article 6959

2021

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1,25‐Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2‐antioxidant signaling and inactivation of p16/p53‐senescence signaling

Aging cell, 2019-06, Vol.18 (3), p.e12951-n/a

2019

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Control of the Restriction Point by Rb and p21

Proceedings of the National Academy of Sciences - PNAS, 2018-08, Vol.115 (35), p.E8219-E8227

2018

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Serpine 1 induces alveolar type II cell senescence through activating p53‐p21‐Rb pathway in fibrotic lung disease

Aging cell, 2017-10, Vol.16 (5), p.1114-1124

2017

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Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

Genes & development, 2013-05, Vol.27 (10), p.1101-1114

2013

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p21: A Two-Faced Genome Guardian

Trends in molecular medicine, 2017-04, Vol.23 (4), p.310-319

2017

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Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK

Nature communications, 2016-05, Vol.7 (1), p.11363-13, Article 11363

2016

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Competing memories of mitogen and p53 signalling control cell-cycle entry

Nature (London), 2017-09, Vol.549 (7672), p.404

2017

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p53 directs leader cell behavior, migration, and clearance during epithelial repair

Science (American Association for the Advancement of Science), 2022-02, Vol.375 (6581), p.eabl8876-eabl8876

2022

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Targeted clearance of p21‐ but not p16‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity

Aging cell, 2022-05, Vol.21 (5), p.e13602-n/a

2022

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DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression

Nature communications, 2017-03, Vol.8 (1), p.14728-14728, Article 14728

2017

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AUF1 ligand circPCNX reduces cell proliferation by competing with p21 mRNA to increase p21 production

Nucleic acids research, 2021-02, Vol.49 (3), p.1631

2021

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p21(WAF1) Mediates Cell-Cycle Inhibition, Relevant to Cancer Suppression and Therapy

Cancer research (Chicago, Ill.), 2016-09, Vol.76 (18), p.5189-5191

El-Deiry, Wafik S

2016

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Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer

Nucleic acids research, 2009-04, Vol.37 (5), p.1672

2009

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Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2

p21 produces a bioactive secretome that places stressed cells under immunosurveillance

Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo

Cell cycle regulation: p53-p21-RB signaling

Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2

Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2‐independent mechanism

Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo

SP1-induced upregulation of the long noncoding RNA TINCR regulates cell proliferation and apoptosis by affecting KLF2 mRNA stability in gastric cancer

Valproate, in Combination with Pemetrexed and Cisplatin, Provides Additional Efficacy to the Treatment of Malignant Mesothelioma

Absence of cyclin-dependent kinase inhibitor p27 or p18 increases efficiency of iPSC generation without induction of iPSC genomic instability

The NUCKS1-SKP2-p21/p27 axis controls S phase entry

1,25‐Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2‐antioxidant signaling and inactivation of p16/p53‐senescence signaling

Control of the Restriction Point by Rb and p21

Serpine 1 induces alveolar type II cell senescence through activating p53‐p21‐Rb pathway in fibrotic lung disease

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

p21: A Two-Faced Genome Guardian

Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK

Competing memories of mitogen and p53 signalling control cell-cycle entry

p53 directs leader cell behavior, migration, and clearance during epithelial repair

Targeted clearance of p21‐ but not p16‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity

DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression

AUF1 ligand circPCNX reduces cell proliferation by competing with p21 mRNA to increase p21 production

p21(WAF1) Mediates Cell-Cycle Inhibition, Relevant to Cancer Suppression and Therapy

Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer

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