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TPX-0131, a Potent CNS-penetrant, Next-generation Inhibitor of Wild-type ALK and ALK-resistant Mutations

Molecular cancer therapeutics, 2021-09, Vol.20 (9), p.1499-1507

2021

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Discovery, Characterization, and Structure−Activity Relationships Studies of Proapoptotic Polyphenols Targeting B-Cell Lymphocyte/Leukemia-2 Proteins

Journal of medicinal chemistry, 2003-09, Vol.46 (20), p.4259-4264

2003

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Multi-Interference and Multi-Model Dynamic Scheduling of the Small Satellite Based on Dual Population Genetic Algorithm

網際網路技術學刊, 2023-11, Vol.24 (6), p.1199-1209

2023

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Humanin peptide suppresses apoptosis by interfering with Bax activation

Nature (London), 2003-05, Vol.423 (6938), p.456-461

2003

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Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation

PloS one, 2011-06, Vol.6 (6), p.e19783

2011

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Differential Regulation of Bax and Bak by Anti-apoptotic Bcl-2 Family Proteins Bcl-B and Mcl-1

The Journal of biological chemistry, 2008-04, Vol.283 (15), p.9580-9586

2008

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Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic bcl-2-family proteins

Cancer research (Chicago, Ill.), 2003-12, Vol.63 (23), p.8118-8121

2003

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Vaccinia Virus Virulence Factor N1L is a Novel Promising Target for Antiviral Therapeutic Intervention

Journal of medicinal chemistry, 2010-05, Vol.53 (10), p.3899-3906

2010

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Expression, purification, and characterization of recombinant NOD1 (NLRC1): A NLR family member

Journal of biotechnology, 2012-01, Vol.157 (1), p.75-81

2012

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Mechanism of Bcl-2 and Bcl-XL inhibition of NLRP1 inflammasome: Loop domain-dependent suppression of ATP binding and oligomerization

Proceedings of the National Academy of Sciences - PNAS, 2009-03, Vol.106 (10), p.3935-3940

2009

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Abstract 2132: The novel, rationally-designed, ALK/SRC inhibitor TPX-0005 overcomes multiple acquired resistance mechanisms to current ALK inhibitors

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.2132-2132

2016

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Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins

Molecular cancer therapeutics, 2008-06, Vol.7 (6), p.1639-1646

2008

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Heterocyclic α-helix mimetics for targeting protein–protein interactions

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (16), p.4641-4645

2007

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Synthetic substrates for measuring activity of autophagy proteases-autophagins (Atg4): Autophagins (Atg4)

Autophagy, 2010-10, Vol.6 (7), p.936-947

2010

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Humanin Binds and Nullifies Bid Activity by Blocking Its Activation of Bax and Bak

The Journal of biological chemistry, 2005-04, Vol.280 (16), p.15815-15824

2005

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Apogossypol Derivatives as Pan-Active Inhibitors of Antiapoptotic B-Cell Lymphoma/Leukemia-2 (Bcl-2) Family Proteins

Journal of medicinal chemistry, 2009-07, Vol.52 (14), p.4511-4523

2009

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Regulation of p53 Localization and Activity by Ubc13

Molecular and Cellular Biology, 2006-12, Vol.26 (23), p.8901-8913

2006

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High-throughput fluorescence assay for small-molecule inhibitors of autophagins/Atg4

Journal of biomolecular screening, 2011-02, Vol.16 (2), p.174-182

2011

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Structure-Activity Relationships by Interligand NOE-Based Design and Synthesis of Antiapoptotic Compounds Targeting Bid

Proceedings of the National Academy of Sciences - PNAS, 2006-08, Vol.103 (33), p.12602-12606

2006

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Vaccinia Virus Protein F1L Is a Caspase-9 Inhibitor

The Journal of biological chemistry, 2010-02, Vol.285 (8), p.5569-5580

2010

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Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL

The Journal of biological chemistry, 2005-04, Vol.280 (16), p.15825-15835

2005

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Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma

Blood, 2007-05, Vol.109 (9), p.3849-3855

2007

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Correction: Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation

PloS one, 2015-12, Vol.10 (12), p.e0146210-e0146210

2015

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Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins

Molecular cancer therapeutics, 2009-04, Vol.8 (4), p.904-913

2009

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TPX-0131, a Potent CNS-penetrant, Next-generation Inhibitor of Wild-type ALK and ALK-resistant Mutations

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

Discovery, Characterization, and Structure−Activity Relationships Studies of Proapoptotic Polyphenols Targeting B-Cell Lymphocyte/Leukemia-2 Proteins

Multi-Interference and Multi-Model Dynamic Scheduling of the Small Satellite Based on Dual Population Genetic Algorithm

Humanin peptide suppresses apoptosis by interfering with Bax activation

Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation

Differential Regulation of Bax and Bak by Anti-apoptotic Bcl-2 Family Proteins Bcl-B and Mcl-1

Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic bcl-2-family proteins

Vaccinia Virus Virulence Factor N1L is a Novel Promising Target for Antiviral Therapeutic Intervention

Expression, purification, and characterization of recombinant NOD1 (NLRC1): A NLR family member

Mechanism of Bcl-2 and Bcl-XL inhibition of NLRP1 inflammasome: Loop domain-dependent suppression of ATP binding and oligomerization

Abstract 2132: The novel, rationally-designed, ALK/SRC inhibitor TPX-0005 overcomes multiple acquired resistance mechanisms to current ALK inhibitors

Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins

Heterocyclic α-helix mimetics for targeting protein–protein interactions

Synthetic substrates for measuring activity of autophagy proteases-autophagins (Atg4): Autophagins (Atg4)

Humanin Binds and Nullifies Bid Activity by Blocking Its Activation of Bax and Bak

Apogossypol Derivatives as Pan-Active Inhibitors of Antiapoptotic B-Cell Lymphoma/Leukemia-2 (Bcl-2) Family Proteins

Regulation of p53 Localization and Activity by Ubc13

High-throughput fluorescence assay for small-molecule inhibitors of autophagins/Atg4

Structure-Activity Relationships by Interligand NOE-Based Design and Synthesis of Antiapoptotic Compounds Targeting Bid

Vaccinia Virus Protein F1L Is a Caspase-9 Inhibitor

Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL

Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma

Correction: Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation

Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins

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