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Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation

ACS medicinal chemistry letters, 2022-07, Vol.13 (7), p.1182-1190

2022

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Trends in Hit-to-Lead Optimization Following DNA-Encoded Library Screens

ACS medicinal chemistry letters, 2021-03, Vol.12 (3), p.343-350

2021

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Recent progress in the discovery of non-sarcosine based GlyT1 inhibitors

Current topics in medicinal chemistry, 2010-02, Vol.10 (2), p.170

2010

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Mechanisms of in Situ Activation for DNA-Targeting Antitumor Agents

Chemical reviews, 2002-07, Vol.102 (7), p.2477-2496

2002

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Efficient Synthesis of Imidazoles from Aldehydes and 1,2-Diketones Using Microwave Irradiation

Organic letters, 2004-04, Vol.6 (9), p.1453-1456

2004

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General microwave-assisted protocols for the expedient synthesis of quinoxalines and heterocyclic pyrazines

Tetrahedron letters, 2004-06, Vol.45 (25), p.4873-4876

2004

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Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia

Current topics in medicinal chemistry, 2006-04, Vol.6 (8), p.771

2006

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Enabling Deoxygenative C(sp2)‑C(sp3) Cross-Coupling for Parallel Medicinal Chemistry

ACS medicinal chemistry letters, 2023-06, Vol.14 (6), p.853-859

2023

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Reducing Limitation in Probe Design: The Development of a Diazirine-Compatible Suzuki–Miyaura Cross Coupling Reaction

ACS medicinal chemistry letters, 2019-01, Vol.10 (1), p.56-61

2019

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Progress in the preparation and testing of glycine transporter type-1 (GlyT1) inhibitors

Current topics in medicinal chemistry, 2006-09, Vol.6 (17), p.1883

2006

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Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction

ACS medicinal chemistry letters, 2021-04, Vol.12 (4), p.540-547

2021

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Benzoxazolinone aryl sulfonamides as potent, selective Nav1.7 inhibitors with in vivo efficacy in a preclinical pain model

Bioorganic & medicinal chemistry letters, 2017-06, Vol.27 (12), p.2683-2688

2017

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Total Synthesis of Anhydrolycorinone Utilizing Sequential Intramolecular Diels−Alder Reactions of a 1,3,4-Oxadiazole

Journal of organic chemistry, 2002-10, Vol.67 (21), p.7361-7364

2002

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Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT)

ACS medicinal chemistry letters, 2015-03, Vol.6 (3), p.318-323

2015

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Intramolecular Diels−Alder and Tandem Intramolecular Diels−Alder/1,3-Dipolar Cycloaddition Reactions of 1,3,4-Oxadiazoles

Journal of the American Chemical Society, 2002-09, Vol.124 (38), p.11292-11294

2002

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Design, Synthesis, and Evaluation of Novel 3,6-Diaryl-4-aminoalkoxyquinolines as Selective Agonists of Somatostatin Receptor Subtype 2

Journal of medicinal chemistry, 2011-04, Vol.54 (7), p.2351-2358

2011

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Synthesis and optimization of N-heterocyclic pyridinones as catechol-O-methyltransferase (COMT) inhibitors

Bioorganic & medicinal chemistry letters, 2016-06, Vol.26 (12), p.2952-2956

2016

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Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (4), p.1062-1069

2017

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Total Synthesis of Amaryllidaceae Alkaloids Utilizing Sequential Intramolecular Heterocyclic Azadiene Diels−Alder Reactions of an Unsymmetrical 1,2,4,5-Tetrazine

Journal of organic chemistry, 2000-12, Vol.65 (26), p.9120-9124

2000

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Benzoxazolinone aryl sulfonamides as potent, selective Na v 1.7 inhibitors with in vivo efficacy in a preclinical pain model

Bioorganic & medicinal chemistry letters, 2017-06, Vol.27 (12), p.2683-2688

2017

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Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs)

Bioorganic & medicinal chemistry, 2008-01, Vol.18 (2), p.554-559

2008

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DNA Alkylation Properties of Yatakemycin

Journal of the American Chemical Society, 2003-09, Vol.125 (36), p.10971-10976

2003

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Total Synthesis and Evaluation of Cytostatin, Its C10−C11 Diastereomers, and Additional Key Analogues: Impact on PP2A Inhibition

Journal of the American Chemical Society, 2006-12, Vol.128 (51), p.16720-16732

2006

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The synthesis and preclinical evaluation in rhesus monkey of [18F]MK-6577 and [11C]CMPyPB glycine transporter 1 positron emission tomography radiotracers

Synapse (New York, N.Y.), 2011-04, Vol.65 (4), p.261-270

2011

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Rational Design, Synthesis, and Evaluation of Key Analogues of CC-1065 and the Duocarmycins

Journal of the American Chemical Society, 2007-11, Vol.129 (45), p.14092-14099

2007

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Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation

Trends in Hit-to-Lead Optimization Following DNA-Encoded Library Screens

Recent progress in the discovery of non-sarcosine based GlyT1 inhibitors

Mechanisms of in Situ Activation for DNA-Targeting Antitumor Agents

Efficient Synthesis of Imidazoles from Aldehydes and 1,2-Diketones Using Microwave Irradiation

General microwave-assisted protocols for the expedient synthesis of quinoxalines and heterocyclic pyrazines

Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia

Enabling Deoxygenative C(sp2)‑C(sp3) Cross-Coupling for Parallel Medicinal Chemistry

Reducing Limitation in Probe Design: The Development of a Diazirine-Compatible Suzuki–Miyaura Cross Coupling Reaction

Progress in the preparation and testing of glycine transporter type-1 (GlyT1) inhibitors

Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction

Benzoxazolinone aryl sulfonamides as potent, selective Nav1.7 inhibitors with in vivo efficacy in a preclinical pain model

Total Synthesis of Anhydrolycorinone Utilizing Sequential Intramolecular Diels−Alder Reactions of a 1,3,4-Oxadiazole

Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT)

Intramolecular Diels−Alder and Tandem Intramolecular Diels−Alder/1,3-Dipolar Cycloaddition Reactions of 1,3,4-Oxadiazoles

Design, Synthesis, and Evaluation of Novel 3,6-Diaryl-4-aminoalkoxyquinolines as Selective Agonists of Somatostatin Receptor Subtype 2

Synthesis and optimization of N-heterocyclic pyridinones as catechol-O-methyltransferase (COMT) inhibitors

Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics

Total Synthesis of Amaryllidaceae Alkaloids Utilizing Sequential Intramolecular Heterocyclic Azadiene Diels−Alder Reactions of an Unsymmetrical 1,2,4,5-Tetrazine

Benzoxazolinone aryl sulfonamides as potent, selective Na v 1.7 inhibitors with in vivo efficacy in a preclinical pain model

Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs)

DNA Alkylation Properties of Yatakemycin

Total Synthesis and Evaluation of Cytostatin, Its C10−C11 Diastereomers, and Additional Key Analogues: Impact on PP2A Inhibition

The synthesis and preclinical evaluation in rhesus monkey of [18F]MK-6577 and [11C]CMPyPB glycine transporter 1 positron emission tomography radiotracers

Rational Design, Synthesis, and Evaluation of Key Analogues of CC-1065 and the Duocarmycins

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