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Eribulin Induces Irreversible Mitotic Blockade: Implications of Cell-Based Pharmacodynamics for In vivo Efficacy under Intermittent Dosing Conditions

Cancer research (Chicago, Ill.), 2011-01, Vol.71 (2), p.496-505

2011

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Comparison of Neuropathy-Inducing Effects of Eribulin Mesylate, Paclitaxel, and Ixabepilone in Mice

Cancer research (Chicago, Ill.), 2011-06, Vol.71 (11), p.3952-3962

2011

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Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389

Cancer research (Chicago, Ill.), 2004-08, Vol.64 (16), p.5760-5766

2004

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Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin

Molecular cancer therapeutics, 2009-10, Vol.8 (10), p.2852-2860

2009

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In Vitro and In Vivo Anticancer Activities of Synthetic (-)-Laulimalide, a Marine Natural Product Microtubule Stabilizing Agent

Anticancer research, 2007-05, Vol.27 (3B), p.1509-1518

2007

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Novel second generation analogs of eribulin. Part III: Blood–brain barrier permeability and in vivo activity in a brain tumor model

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1639-1643

2011

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Novel second generation analogs of eribulin. Part I: Compounds containing a lipophilic C32 side chain overcome P-glycoprotein susceptibility

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1630-1633

2011

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Broad-spectrum Preclinical Antitumor Activity of Eribulin (Halaven®): Combination with Anticancer Agents of Differing Mechanisms

Anticancer research, 2018-06, Vol.38 (6), p.3375-3385

2018

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Broad Spectrum Preclinical Antitumor Activity of Eribulin (Halaven®): Optimal Effectiveness under Intermittent Dosing Conditions

Anticancer research, 2012-05, Vol.32 (5), p.1611-1619

2012

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Anti-angiogenesis Effects of Borrelidin are Mediated through Distinct Pathways: Threonyl-tRNA Synthetase and Caspases are Independently Involved in Suppression of Proliferation and Induction of Apoptosis in Endothelial Cells

The Journal of Antibiotics, 2003/08/25, Vol.56(8), pp.709-715

2003

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In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B

Cancer research (Chicago, Ill.), 2001-02, Vol.61 (3), p.1013-1021

2001

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Macrocyclic ketone analogues of halichondrin B

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (22), p.5551-5554

2004

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Novel second generation analogs of eribulin. Part II: Orally available and active against resistant tumors in vivo

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1634-1638

2011

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Structurally simplified macrolactone analogues of halichondrin B

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (22), p.5547-5550

2004

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Inhibition of urokinase by 4-substituted benzo[b]thiophene-2-carboxamidines : an important new class of selective synthetic urokinase inhibitor

Cancer research (Chicago, Ill.), 1993-06, Vol.53 (11), p.2553-2559

1993

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Abstract 4438: Comparison of neuropathy-inducing effects of eribulin versus paclitaxel in mice

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.4438-4438

2010

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The synthesis of three 4-substitutedbenzo[ b]thiophene-2-carboxamidines as potent and selective inhibitors of urokinase

Bioorganic & medicinal chemistry, 1993, Vol.1 (6), p.403-410

1993

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Denufosol Tetrasodium in Patients with Cystic Fibrosis and Normal to Mildly Impaired Lung Function

American journal of respiratory and critical care medicine, 2011-03, Vol.183 (5), p.627-634

2011

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Isolation and characterization of rat cDNA clones for two distinct thyroid hormone receptors

The Journal of biological chemistry, 1988-09, Vol.263 (25), p.12770-12777

1988

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Incorporating Interactive Examples into the Cognitive Tutor

Intelligent Tutoring Systems, p.446-446

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A Cognitive Tutor for Geometric Proof

Intelligent Tutoring Systems, p.453-453

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Research-Based Improvements in Cognitive Tutor Geometry

Intelligent Tutoring Systems, p.452-452

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Predicting the Effects of Skill Model Changes on Student Progress

Intelligent Tutoring Systems, p.300-302

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Circulating monoclonal B lymphocytes in non-Hodgkin's lymphoma

The New England journal of medicine, 1984-12, Vol.311 (23), p.1476-1481

1984

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Isolation and characterization of rat cDNA clones for two distinct thyroid hormone receptors

The Journal of biological chemistry, 1985-01, Vol.263 (25), p.12770-12777

1985

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Eribulin Induces Irreversible Mitotic Blockade: Implications of Cell-Based Pharmacodynamics for In vivo Efficacy under Intermittent Dosing Conditions

Comparison of Neuropathy-Inducing Effects of Eribulin Mesylate, Paclitaxel, and Ixabepilone in Mice

Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389

Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin

In Vitro and In Vivo Anticancer Activities of Synthetic (-)-Laulimalide, a Marine Natural Product Microtubule Stabilizing Agent

Novel second generation analogs of eribulin. Part III: Blood–brain barrier permeability and in vivo activity in a brain tumor model

Novel second generation analogs of eribulin. Part I: Compounds containing a lipophilic C32 side chain overcome P-glycoprotein susceptibility

Broad-spectrum Preclinical Antitumor Activity of Eribulin (Halaven®): Combination with Anticancer Agents of Differing Mechanisms

Broad Spectrum Preclinical Antitumor Activity of Eribulin (Halaven®): Optimal Effectiveness under Intermittent Dosing Conditions

Anti-angiogenesis Effects of Borrelidin are Mediated through Distinct Pathways: Threonyl-tRNA Synthetase and Caspases are Independently Involved in Suppression of Proliferation and Induction of Apoptosis in Endothelial Cells

In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B

Macrocyclic ketone analogues of halichondrin B

Novel second generation analogs of eribulin. Part II: Orally available and active against resistant tumors in vivo

Structurally simplified macrolactone analogues of halichondrin B

Inhibition of urokinase by 4-substituted benzo[b]thiophene-2-carboxamidines : an important new class of selective synthetic urokinase inhibitor

Abstract 4438: Comparison of neuropathy-inducing effects of eribulin versus paclitaxel in mice

The synthesis of three 4-substitutedbenzo[ b]thiophene-2-carboxamidines as potent and selective inhibitors of urokinase

Denufosol Tetrasodium in Patients with Cystic Fibrosis and Normal to Mildly Impaired Lung Function

Isolation and characterization of rat cDNA clones for two distinct thyroid hormone receptors

Incorporating Interactive Examples into the Cognitive Tutor

A Cognitive Tutor for Geometric Proof

Research-Based Improvements in Cognitive Tutor Geometry

Predicting the Effects of Skill Model Changes on Student Progress

Circulating monoclonal B lymphocytes in non-Hodgkin's lymphoma

Isolation and characterization of rat cDNA clones for two distinct thyroid hormone receptors

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