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Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression

Nature communications, 2020-06, Vol.11 (1), p.3243-16, Article 3243

2020

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Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors

Cell reports (Cambridge), 2023-07, Vol.42 (7), p.112764-112764, Article 112764

2023

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Models from experiments: combinatorial drug perturbations of cancer cells

Molecular systems biology, 2008, Vol.4 (1), p.216-n/a

2008

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N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals

Nature communications, 2019-08, Vol.10 (1), p.3708-16, Article 3708

2019

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

Cancer research (Chicago, Ill.), 2006-02, Vol.66 (3), p.1500-1508

2006

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A Divergent Enantioselective Strategy for the Synthesis of Griseusins

Angewandte Chemie (International ed.), 2015-09, Vol.54 (38), p.11219-11222

International ed. in English, 2015

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Loss of 4E-BP1 function induces EMT and promotes cancer cell migration and invasion via cap-dependent translational activation of snail

Oncotarget, 2014-08, Vol.5 (15), p.6015-6027

2014

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AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis

Oncotarget, 2015-06, Vol.6 (16), p.13962-13977

2015

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PIK3CA Mutation Uncouples Tumor Growth and Cyclin D1 Regulation from MEK/ERK and Mutant KRAS Signaling

Cancer research (Chicago, Ill.), 2010-09, Vol.70 (17), p.6804-6814

2010

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Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity

Proceedings of the National Academy of Sciences - PNAS, 2007-05, Vol.104 (18), p.7564-7569

2007

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Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects

Cell chemical biology, 2019-03, Vol.26 (3), p.366-377.e12

2019

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The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells

Cancer cell, 2005-10, Vol.8 (4), p.287-297

2005

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Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1

Nature communications, 2017-12, Vol.8 (1), p.2207-15, Article 2207

2017

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Beta-catenin cleavage enhances transcriptional activation

Scientific reports, 2018-01, Vol.8 (1), p.671-15, Article 671

2018

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Resistance to Gefitinib in PTEN-Null HER-Overexpressing Tumor Cells Can Be Overcome through Restoration of PTEN Function or Pharmacologic Modulation of Constitutive Phosphatidylinositol 3′-Kinase/Akt Pathway Signaling

Clinical cancer research, 2003-10, Vol.9 (12), p.4340-4346

2003

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4E-BP1 Is a Key Effector of the Oncogenic Activation of the AKT and ERK Signaling Pathways that Integrates Their Function in Tumors

Cancer cell, 2010-07, Vol.18 (1), p.39-51

2010

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A Diastereoselective Oxa-Pictet–Spengler-Based Strategy for (+)-Frenolicin B and epi-(+)-Frenolicin B Synthesis

Organic letters, 2013-11, Vol.15 (21), p.5566-5569

2013

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CD151-α3β1 integrin complexes suppress ovarian tumor growth by repressing slug-mediated EMT and canonical Wnt signaling

Oncotarget, 2014-12, Vol.5 (23), p.12203-12217

2014

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ERKs and p38 Kinase Phosphorylate p53 Protein at Serine 15 in Response to UV Radiation

The Journal of biological chemistry, 2000-07, Vol.275 (27), p.20444-20449

2000

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Targeting Squalene Epoxidase Interrupts Homologous Recombination via the ER Stress Response and Promotes Radiotherapy Efficacy

Cancer research (Chicago, Ill.), 2022-04, Vol.82 (7), p.1298-1312

2022

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An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo

Cancer biology & therapy, 2010-04, Vol.9 (7), p.493-503

2010

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4E-BP1 as an oncotarget

Aging (Albany, NY.), 2015-08, Vol.7 (8), p.517-518

She, Qing-Bai

2015

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Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling

PloS one, 2008-08, Vol.3 (8), p.e3065

2008

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The Identification of Perillyl Alcohol Glycosides with Improved Antiproliferative Activity

Journal of medicinal chemistry, 2014-09, Vol.57 (17), p.7478-7484

2014

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AKT and cancer—Is it all mTOR?

Cancer cell, 2006-10, Vol.10 (4), p.254-256

2006

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Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression

Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors

Models from experiments: combinatorial drug perturbations of cancer cells

N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

A Divergent Enantioselective Strategy for the Synthesis of Griseusins

Loss of 4E-BP1 function induces EMT and promotes cancer cell migration and invasion via cap-dependent translational activation of snail

AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis

PIK3CA Mutation Uncouples Tumor Growth and Cyclin D1 Regulation from MEK/ERK and Mutant KRAS Signaling

Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity

Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects

The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells

Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1

Beta-catenin cleavage enhances transcriptional activation

Resistance to Gefitinib in PTEN-Null HER-Overexpressing Tumor Cells Can Be Overcome through Restoration of PTEN Function or Pharmacologic Modulation of Constitutive Phosphatidylinositol 3′-Kinase/Akt Pathway Signaling

4E-BP1 Is a Key Effector of the Oncogenic Activation of the AKT and ERK Signaling Pathways that Integrates Their Function in Tumors

A Diastereoselective Oxa-Pictet–Spengler-Based Strategy for (+)-Frenolicin B and epi-(+)-Frenolicin B Synthesis

CD151-α3β1 integrin complexes suppress ovarian tumor growth by repressing slug-mediated EMT and canonical Wnt signaling

ERKs and p38 Kinase Phosphorylate p53 Protein at Serine 15 in Response to UV Radiation

Targeting Squalene Epoxidase Interrupts Homologous Recombination via the ER Stress Response and Promotes Radiotherapy Efficacy

An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo

4E-BP1 as an oncotarget

Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling

The Identification of Perillyl Alcohol Glycosides with Improved Antiproliferative Activity

AKT and cancer—Is it all mTOR?

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