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LGALS1 acts as a pro-survival molecule in AML

Biochimica et biophysica acta. Molecular cell research, 2020-10, Vol.1867 (10), p.118785-118785, Article 118785

2020

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The Dual MEK/FLT3 Inhibitor E6201 Exerts Cytotoxic Activity against Acute Myeloid Leukemia Cells Harboring Resistance-Conferring FLT3 Mutations

Cancer research (Chicago, Ill.), 2016-03, Vol.76 (6), p.1528-1537

2016

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Distinct protein signatures of acute myeloid leukemia bone marrow-derived stromal cells are prognostic for patient survival

Haematologica (Roma), 2018-05, Vol.103 (5), p.810-821

2018

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Combination of galectin inhibitor GCS-100 and BH3 mimetics eliminates both p53 wild type and p53 null AML cells

Biochimica et biophysica acta, 2016-04, Vol.1863 (4), p.562-571

2016

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Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML

Leukemia, 2021-09, Vol.35 (9), p.2469-2481

2021

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Inhibition of Mcl-1 with the pan–Bcl-2 family inhibitor (–)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia

Blood, 2015-07, Vol.126 (3), p.363-372

2015

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Targeting PKC-mediated signal transduction pathways using enzastaurin to promote apoptosis in acute myeloid leukemia-derived cell lines and blast cells

Journal of cellular biochemistry, 2011-06, Vol.112 (6), p.1696-1707

2011

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Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia

Blood, 2016-09, Vol.128 (9), p.1260-1269

2016

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Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models

Haematologica (Roma), 2020-03, Vol.105 (3), p.697-707

2020

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AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3 -ITD acute myeloid leukemia

Haematologica (Roma), 2022-06, Vol.107 (6), p.1311-1322

2022

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Mitochondrial regulation of GPX4 inhibition-mediated ferroptosis in acute myeloid leukemia

Leukemia, 2024-04, Vol.38 (4), p.729-740

2024

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Targeting Unc51-like Autophagy Activating Kinase 1 (ULK1) Overcomes Adaptive Drug Resistance in Acute Myelogenous Leukemia

Molecular cancer research, 2023-06, Vol.21 (6), p.548

2023

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Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms

Haematologica (Roma), 2017-12, Vol.102 (12), p.2048-2057

2017

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Focal Adhesion Kinase as a Potential Target in AML and MDS

Molecular cancer therapeutics, 2017-06, Vol.16 (6), p.1133-1144

2017

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Role of MSC-derived galectin 3 in the AML microenvironment

Biochimica et biophysica acta. Molecular cell research, 2018-07, Vol.1865 (7), p.959-969

2018

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Human Glycolipid Transfer Protein Gene (GLTP) Expression Is Regulated by Sp1 and Sp3

The Journal of biological chemistry, 2011-01, Vol.286 (2), p.1301-1311

2011

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Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms

Haematologica (Roma), 2017-12, Vol.102 (12), p.2048-2057

2017

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The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells

Biochimica et biophysica acta, 2014-09, Vol.1843 (9), p.1969-1977

2014

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AML-147 C-MYC Targeting by Degradation: Novel Dual c-Myc/GSPT1 Degrader GT19715 Exerts Profound Cell Kill In Vitro and In Vivo in Acute Myeloid Leukemia and Lymphomas

Clinical lymphoma, myeloma and leukemia, 2022-10, Vol.22, p.S218

2022

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Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells

Molecular cancer therapeutics, 2014-07, Vol.13 (7), p.1848-1859

2014

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Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells

Oncotarget, 2017-09, Vol.8 (44), p.76525-76557

2017

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Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34+ proliferating and quiescent chronic myeloid leukemia blast crisis cells

Oncotarget, 2015-10, Vol.6 (31), p.30487-30499

2015

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LGALS3 is connected to CD74 in a previously unknown protein network that is associated with poor survival in patients with AML

EBioMedicine, 2019-06, Vol.44, p.126-137

2019

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Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality

LGALS1 acts as a pro-survival molecule in AML

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

The Dual MEK/FLT3 Inhibitor E6201 Exerts Cytotoxic Activity against Acute Myeloid Leukemia Cells Harboring Resistance-Conferring FLT3 Mutations

Distinct protein signatures of acute myeloid leukemia bone marrow-derived stromal cells are prognostic for patient survival

Combination of galectin inhibitor GCS-100 and BH3 mimetics eliminates both p53 wild type and p53 null AML cells

Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML

Inhibition of Mcl-1 with the pan–Bcl-2 family inhibitor (–)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia

Targeting PKC-mediated signal transduction pathways using enzastaurin to promote apoptosis in acute myeloid leukemia-derived cell lines and blast cells

Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia

Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models

AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3 -ITD acute myeloid leukemia

Mitochondrial regulation of GPX4 inhibition-mediated ferroptosis in acute myeloid leukemia

Targeting Unc51-like Autophagy Activating Kinase 1 (ULK1) Overcomes Adaptive Drug Resistance in Acute Myelogenous Leukemia

Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms

Focal Adhesion Kinase as a Potential Target in AML and MDS

Role of MSC-derived galectin 3 in the AML microenvironment

Human Glycolipid Transfer Protein Gene (GLTP) Expression Is Regulated by Sp1 and Sp3

Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms

The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells

AML-147 C-MYC Targeting by Degradation: Novel Dual c-Myc/GSPT1 Degrader GT19715 Exerts Profound Cell Kill In Vitro and In Vivo in Acute Myeloid Leukemia and Lymphomas

Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells

Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells

Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34+ proliferating and quiescent chronic myeloid leukemia blast crisis cells

LGALS3 is connected to CD74 in a previously unknown protein network that is associated with poor survival in patients with AML

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