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(421) CR845, a novel peripherally-acting kappa opioid receptor agonist, has low abuse potential compared with pentazocine

The journal of pain, 2015-04, Vol.16 (4), p.S81-S81

2015

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(422) CR845, a peripheral kappa opioid, provides better pain relief with less nausea and vomiting than placebo in patients after bunionectomy

The journal of pain, 2015-04, Vol.16 (4), p.S81-S81

2015

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Sites of Neocortical Reorganization Critical for Remote Spatial Memory

Science (American Association for the Advancement of Science), 2004-07, Vol.305 (5680), p.96-99

2004

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PUK28 EMULATING EQ-5D DATA FROM AVAILABLE PROS TO OPTIMIZE CLINICAL TRIAL PLANNING IN CHRONIC KIDNEY DISEASE-ASSOCIATED PRURITUS

Value in health, 2019-11, Vol.22, p.S918-S918

2019

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PUK31 ESTIMATING THE IMPACT OF TREATING CHRONIC KIDNEY DISEASE-ASSOCIATED PRURITUS ON QUALITY OF LIFE IN THE ABSENCE OF DIRECT UTILITY MEASURES

Value in health, 2019-11, Vol.22, p.S919-S919

2019

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The subtype-selective nicotinic acetylcholine receptor agonist SIB-1553A improves both attention and memory components of a spatial working memory task in chronic low dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys

The Journal of pharmacology and experimental therapeutics, 2003-07, Vol.306 (1), p.401

2003

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Antidepressant-like effects of the subtype-selective nicotinic acetylcholine receptor agonist, SIB-1508Y, in the learned helplessness rat model of depression

Psychopharmacology, 2000-10, Vol.152 (3), p.295-303

2000

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Self-reported Pruritus and Clinical, Dialysis-Related, and Patient-Reported Outcomes in Hemodialysis Patients

Kidney medicine, 2021-01, Vol.3 (1), p.42-53.e1

2021

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583 Psychometric validation and meaningful change threshold of the worst itching intensity numerical rating scale for use in hemodialysis patients with pruritus

Journal of investigative dermatology, 2018-05, Vol.138 (5), p.S99-S99

2018

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1089 Antipruritic effect of the novel kappa opioid receptor agonist CR845

Journal of investigative dermatology, 2018-05, Vol.138 (5), p.S185-S185

2018

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Characterization of a novel and potent corticotropin-releasing factor antagonist in rats

The Journal of pharmacology and experimental therapeutics, 1994-05, Vol.269 (2), p.564

1994

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Corticotropin-releasing factor (CRF) antagonist [D-Phe12,Nle21,38,C alpha MeLeu37]CRF attenuates the acute actions of the highly potent cannabinoid receptor agonist HU-210 on defensive-withdrawal behavior in rats

The Journal of pharmacology and experimental therapeutics, 1996-01, Vol.276 (1), p.56

1996

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Antagonist of nicotinic acetylcholine receptors (nAChR) enhances formalin-induced nociception in rats: tonic role of nAChRs in the control of pain following injury

Brain research, 2001-01, Vol.888 (1), p.102-106

2001

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582 Measurement of pruritus associated with chronic kidney disease: A qualitative study of two patient-reported outcome instruments

Journal of investigative dermatology, 2018-05, Vol.138 (5), p.S99-S99

2018

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Suppression of corticotropin-releasing factor in the amygdala attenuates aversive consequences of morphine withdrawal

Behavioural pharmacology, 1995-01, Vol.6 (1), p.74-80

1995

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Effects of the nicotinic acetylcholine receptor agonist SIB-1508Y on object retrieval performance in MPTP-Treated monkeys: Comparison with levodopa treatment

Annals of neurology, 1998-03, Vol.43 (3), p.311-317

1998

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POS-601 IMPROVEMENT IN SLEEP QUALITY FROM REDUCTION OF ITCH INTENSITY IN PATIENTS WITH MODERATE-TO-SEVERE PRURITUS UNDERGOING HEMODIALYSIS

Kidney international reports, 2022-02, Vol.7 (2), p.S258-S258

2022

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S625 A PHARMACOKINETIC AND PHARMACODYNAMIC STUDY OF A PERIPHERAL κ-OPIOID RECEPTOR AGONIST CR665 AND OXYCODONE

European journal of pain supplements, 2011-09, Vol.5 (1), p.277-277

2011

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Reduced cerebrospinal fluid levels of α-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits

Neuroscience, 1999-01, Vol.93 (4), p.1409-1420

1999

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The Role of Corticotropin-Releasing Factor in the Anxiogenic Effects of Ethanol Withdrawal

Annals of the New York Academy of Sciences, 1994-10, Vol.739 (1), p.176-184

1994

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The potential of subtype-selective neuronal nicotinic acetylcholine receptor agonists as therapeutic agents

Life sciences (1973), 1998, Vol.62 (17), p.1601-1606

1998

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Pharmacological characterization of SIB-1663, a conformationally rigid analog of nicotine

Brain research, 2004-04, Vol.1003 (1), p.42-53

2004

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Epibatidine: a nicotinic acetylcholine receptor agonist releases monoaminergic neurotransmitters: in vitro and in vivo evidence in rats

The Journal of pharmacology and experimental therapeutics, 1996-02, Vol.276 (2), p.509

1996

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Selective immunolesioning of the basal forebrain cholinergic neurons in rats: effect on attention using the 5-choice serial reaction time task

Psychopharmacologia, 2002-10, Vol.164 (1), p.71-81

2002

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Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity

Bioorganic & medicinal chemistry letters, 2005-03, Vol.15 (5), p.1467-1470

2005

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(421) CR845, a novel peripherally-acting kappa opioid receptor agonist, has low abuse potential compared with pentazocine

(422) CR845, a peripheral kappa opioid, provides better pain relief with less nausea and vomiting than placebo in patients after bunionectomy

Sites of Neocortical Reorganization Critical for Remote Spatial Memory

PUK28 EMULATING EQ-5D DATA FROM AVAILABLE PROS TO OPTIMIZE CLINICAL TRIAL PLANNING IN CHRONIC KIDNEY DISEASE-ASSOCIATED PRURITUS

PUK31 ESTIMATING THE IMPACT OF TREATING CHRONIC KIDNEY DISEASE-ASSOCIATED PRURITUS ON QUALITY OF LIFE IN THE ABSENCE OF DIRECT UTILITY MEASURES

The subtype-selective nicotinic acetylcholine receptor agonist SIB-1553A improves both attention and memory components of a spatial working memory task in chronic low dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys

Antidepressant-like effects of the subtype-selective nicotinic acetylcholine receptor agonist, SIB-1508Y, in the learned helplessness rat model of depression

Self-reported Pruritus and Clinical, Dialysis-Related, and Patient-Reported Outcomes in Hemodialysis Patients

583 Psychometric validation and meaningful change threshold of the worst itching intensity numerical rating scale for use in hemodialysis patients with pruritus

1089 Antipruritic effect of the novel kappa opioid receptor agonist CR845

Characterization of a novel and potent corticotropin-releasing factor antagonist in rats

Corticotropin-releasing factor (CRF) antagonist [D-Phe12,Nle21,38,C alpha MeLeu37]CRF attenuates the acute actions of the highly potent cannabinoid receptor agonist HU-210 on defensive-withdrawal behavior in rats

Antagonist of nicotinic acetylcholine receptors (nAChR) enhances formalin-induced nociception in rats: tonic role of nAChRs in the control of pain following injury

582 Measurement of pruritus associated with chronic kidney disease: A qualitative study of two patient-reported outcome instruments

Suppression of corticotropin-releasing factor in the amygdala attenuates aversive consequences of morphine withdrawal

Effects of the nicotinic acetylcholine receptor agonist SIB-1508Y on object retrieval performance in MPTP-Treated monkeys: Comparison with levodopa treatment

POS-601 IMPROVEMENT IN SLEEP QUALITY FROM REDUCTION OF ITCH INTENSITY IN PATIENTS WITH MODERATE-TO-SEVERE PRURITUS UNDERGOING HEMODIALYSIS

S625 A PHARMACOKINETIC AND PHARMACODYNAMIC STUDY OF A PERIPHERAL κ-OPIOID RECEPTOR AGONIST CR665 AND OXYCODONE

Reduced cerebrospinal fluid levels of α-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits

The Role of Corticotropin-Releasing Factor in the Anxiogenic Effects of Ethanol Withdrawal

The potential of subtype-selective neuronal nicotinic acetylcholine receptor agonists as therapeutic agents

Pharmacological characterization of SIB-1663, a conformationally rigid analog of nicotine

Epibatidine: a nicotinic acetylcholine receptor agonist releases monoaminergic neurotransmitters: in vitro and in vivo evidence in rats

Selective immunolesioning of the basal forebrain cholinergic neurons in rats: effect on attention using the 5-choice serial reaction time task

Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity

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