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Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins

Current opinion in microbiology, 2013-12, Vol.16 (6), p.722-727

2013

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Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments

PLoS pathogens, 2016-12, Vol.12 (12), p.e1006094

2016

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Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics

Metabolomics, 2013-03, Vol.9 (Suppl 1), p.44-66

2013

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Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics

PLoS neglected tropical diseases, 2014-05, Vol.8 (5), p.e2844

2014

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Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution

Nature communications, 2020-06, Vol.11 (1), p.2894-13, Article 2894

2020

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Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action

Antimicrobial agents and chemotherapy, 2016-11, Vol.60 (11), p.6650-6663

2016

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System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion

PLoS pathogens, 2020-06, Vol.16 (6), p.e1008485

2020

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Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

Proceedings of the National Academy of Sciences - PNAS, 2011-03, Vol.108 (11), p.4400-4405

2011

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BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei

PLoS pathogens, 2014-07, Vol.10 (7), p.e1004263-e1004263

2014

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Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose

PLoS pathogens, 2015-03, Vol.11 (3), p.e1004689-e1004689

2015

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Measuring Sulforaphane and Its Metabolites in Human Plasma: A High Throughput Method

Molecules (Basel, Switzerland), 2020-02, Vol.25 (4), p.829

2020

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Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites

PLoS pathogens, 2015-06, Vol.11 (6), p.e1004882

2015

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Relationship between Antimalarial Activity and Heme Alkylation for Spiro- and Dispiro-1,2,4-Trioxolane Antimalarials

Antimicrobial Agents and Chemotherapy, 2008-04, Vol.52 (4), p.1291-1296

2008

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Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii

BMC biology, 2020-06, Vol.18 (1), p.67-67, Article 67

2020

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Current and emerging target identification methods for novel antimalarials

International journal for parasitology -- drugs and drug resistance, 2022-12, Vol.20, p.135-144

2022

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Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate

eLife, 2017-03, Vol.6

2017

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Promising antimalarial hits from phenotypic screens: a review of recently-described multi-stage actives and their modes of action

Frontiers in cellular and infection microbiology, 2023, Vol.13, p.1308193-1308193

2023

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Metabolomics Guides Rational Development of a Simplified Cell Culture Medium for Drug Screening against Trypanosoma brucei

Antimicrobial Agents and Chemotherapy, 2013-06, Vol.57 (6), p.2768-2779

2013

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Non‐canonical metabolic pathways in the malaria parasite detected by isotope‐tracing metabolomics

Molecular systems biology, 2021-04, Vol.17 (4), p.e10023-n/a

2021

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Resensitising proteasome inhibitor-resistant myeloma with sphingosine kinase 2 inhibition

Neoplasia (New York, N.Y.), 2022-01, Vol.24 (1), p.1-11

2022

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The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism

Scientific reports, 2022-01, Vol.12 (1), p.454-454, Article 454

2022

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Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei

PLoS neglected tropical diseases, 2012-05, Vol.6 (5), p.e1618

2012

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Determination of antiprotozoal drug mechanisms by metabolomics approaches

Parasitology, 2014-01, Vol.141 (1), p.83-92

2014

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Integrated metabolomic and transcriptomic analyses of the synergistic effect of polymyxin–rifampicin combination against Pseudomonas aeruginosa

Journal of biomedical science, 2022-10, Vol.29 (1), p.1-89, Article 89

2022

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Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei

PLoS neglected tropical diseases, 2018-05, Vol.12 (5), p.e0006450

2018

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Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins

Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments

Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics

Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics

Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution

Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action

System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei

Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose

Measuring Sulforaphane and Its Metabolites in Human Plasma: A High Throughput Method

Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites

Relationship between Antimalarial Activity and Heme Alkylation for Spiro- and Dispiro-1,2,4-Trioxolane Antimalarials

Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii

Current and emerging target identification methods for novel antimalarials

Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate

Promising antimalarial hits from phenotypic screens: a review of recently-described multi-stage actives and their modes of action

Metabolomics Guides Rational Development of a Simplified Cell Culture Medium for Drug Screening against Trypanosoma brucei

Non‐canonical metabolic pathways in the malaria parasite detected by isotope‐tracing metabolomics

Resensitising proteasome inhibitor-resistant myeloma with sphingosine kinase 2 inhibition

The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism

Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei

Determination of antiprotozoal drug mechanisms by metabolomics approaches

Integrated metabolomic and transcriptomic analyses of the synergistic effect of polymyxin–rifampicin combination against Pseudomonas aeruginosa

Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei

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