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Discovery of Species-selective and Resistance-breaking Anticholinesterase Insecticides for the Malaria Mosquito

Current medicinal chemistry, 2017-08, Vol.24 (27), p.2946

2017

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Antiapicoplast and Gametocytocidal Screening To Identify the Mechanisms of Action of Compounds within the Malaria Box

Antimicrobial Agents and Chemotherapy, 2014-02, Vol.58 (2), p.811-819

2014

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Structural genomics for drug design against the pathogen Coxiella burnetii

Proteins, structure, function, and bioinformatics, 2015-12, Vol.83 (12), p.2124-2136

2015

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Substituted salicylic acid analogs offer improved potency against multidrug-resistant Neisseria gonorrhoeae and good selectivity against commensal vaginal bacteria

Scientific reports, 2023-09, Vol.13 (1), p.14468-14468, Article 14468

2023

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Click Chemistry In Situ: Acetylcholinesterase as a Reaction Vessel for the Selective Assembly of a Femtomolar Inhibitor from an Array of Building Blocks

Angewandte Chemie (International ed.), 2002-03, Vol.41 (6), p.1053-1057

2002

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Discovery of Two Inhibitors of the Type IV Pilus Assembly ATPase PilB as Potential Antivirulence Compounds

Microbiology spectrum, 2022-12, Vol.10 (6), p.e0387722-e0387722

2022

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Stereochemical Inversion of a Cyano-Stabilized Grignard Reagent: Remarkable Effects of the Ethereal Solvent Structure and Concentration

Journal of the American Chemical Society, 2013-09, Vol.135 (38), p.14390-14400

2013

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Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice

Frontiers in cellular neuroscience, 2018-11, Vol.12, p.396-396

2018

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Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles gambiae Reveals Basis of Insecticide Resistance

Structure (London), 2018-01, Vol.26 (1), p.130-136.e2

2018

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Computational Studies of Ion-Pair Separation of Benzylic Organolithium Compounds in THF: Importance of Explicit and Implicit Solvation

Journal of organic chemistry, 2010-02, Vol.75 (4), p.1061-1069

2010

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A computational study of regioselectivity in aluminum hydride ring-opening of cis- and trans-4-t-butyl and 3-methylcyclohexene oxides

Organic & biomolecular chemistry, 2019-09, Vol.17 (37), p.8628-8635

2019

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3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae

Bioorganic & medicinal chemistry, 2015-03, Vol.23 (6), p.1321-1340

2015

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Incremental Solvation Precedes Ion-Pair Separation in Enantiomerization of a Cyano-Stabilized Grignard Reagent

Chemistry : a European journal, 2011-10, Vol.17 (44), p.12250-12253

2011

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The First Enantioenriched Metalated Nitrile Possessing Macroscopic Configurational Stability

Organic letters, 2007-03, Vol.9 (7), p.1319-1322

2007

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Select small core structure carbamates exhibit high contact toxicity to "carbamate-resistant" strain malaria mosquitoes, Anopheles gambiae (Akron)

PloS one, 2012-10, Vol.7 (10), p.e46712

2012

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Access to “Friedel–Crafts-Restricted” tert-Alkyl Aromatics by Activation/Methylation of Tertiary Benzylic Alcohols

Journal of organic chemistry, 2012-04, Vol.77 (7), p.3127-3133

2012

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Promising tacrine/huperzine A‐based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget

Journal of neurochemistry, 2021-09, Vol.158 (6), p.1381-1393

2021

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In vitro and in vivo evaluation of the antimalarial MMV665831 and structural analogs

Bioorganic & medicinal chemistry letters, 2020-09, Vol.30 (17), p.127348-127348, Article 127348

2020

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Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade

Chemico-biological interactions, 2013-03, Vol.203 (1), p.365-370

2013

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Antidepressant-like pharmacological profile of a novel triple reuptake inhibitor, (1S,2S)-3-(methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol (PRC200-SS)

The Journal of pharmacology and experimental therapeutics, 2008-11, Vol.327 (2), p.573

2008

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Questioning the γ-gauche effect: stereoassignment of 1,3-disubstituted-tetrahydro-β-carbolines using H-H coupling constants

Organic & biomolecular chemistry, 2019-07, Vol.17 (27), p.6687-6698

2019

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Novel Dimeric Acetylcholinesterase Inhibitor Bis(7)-tacrine, but Not Donepezil, Prevents Glutamate-induced Neuronal Apoptosis by Blocking N-Methyl-d-aspartate Receptors

The Journal of biological chemistry, 2005-05, Vol.280 (18), p.18179-18188

2005

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Questioning the γ-gauche effect: stereoassignment of 1,3-disubstituted-tetrahydro-β-carbolines using 1H–1H coupling constants

Organic & biomolecular chemistry, 2019-07, Vol.17 (27), p.6687-6698

2019

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Questioning the γ-gauche effect: stereoassignment of 1,3-disubstituted-tetrahydro-β-carbolines using 1 H- 1 H coupling constants

Organic & biomolecular chemistry, 2019-07, Vol.17 (27), p.6687-6698

2019

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Bivalent Carbamates as Novel Control Agents of the Malaria Mosquito, Anopheles gambiae

Chimia, 2016-10, Vol.70 (10), p.704

2016

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Discovery of Species-selective and Resistance-breaking Anticholinesterase Insecticides for the Malaria Mosquito

Antiapicoplast and Gametocytocidal Screening To Identify the Mechanisms of Action of Compounds within the Malaria Box

Structural genomics for drug design against the pathogen Coxiella burnetii

Substituted salicylic acid analogs offer improved potency against multidrug-resistant Neisseria gonorrhoeae and good selectivity against commensal vaginal bacteria

Click Chemistry In Situ: Acetylcholinesterase as a Reaction Vessel for the Selective Assembly of a Femtomolar Inhibitor from an Array of Building Blocks

Discovery of Two Inhibitors of the Type IV Pilus Assembly ATPase PilB as Potential Antivirulence Compounds

Stereochemical Inversion of a Cyano-Stabilized Grignard Reagent: Remarkable Effects of the Ethereal Solvent Structure and Concentration

Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice

Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles gambiae Reveals Basis of Insecticide Resistance

Computational Studies of Ion-Pair Separation of Benzylic Organolithium Compounds in THF: Importance of Explicit and Implicit Solvation

A computational study of regioselectivity in aluminum hydride ring-opening of cis- and trans-4-t-butyl and 3-methylcyclohexene oxides

3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae

Incremental Solvation Precedes Ion-Pair Separation in Enantiomerization of a Cyano-Stabilized Grignard Reagent

The First Enantioenriched Metalated Nitrile Possessing Macroscopic Configurational Stability

Select small core structure carbamates exhibit high contact toxicity to "carbamate-resistant" strain malaria mosquitoes, Anopheles gambiae (Akron)

Access to “Friedel–Crafts-Restricted” tert-Alkyl Aromatics by Activation/Methylation of Tertiary Benzylic Alcohols

Promising tacrine/huperzine A‐based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget

In vitro and in vivo evaluation of the antimalarial MMV665831 and structural analogs

Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade

Antidepressant-like pharmacological profile of a novel triple reuptake inhibitor, (1S,2S)-3-(methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol (PRC200-SS)

Questioning the γ-gauche effect: stereoassignment of 1,3-disubstituted-tetrahydro-β-carbolines using H-H coupling constants

Novel Dimeric Acetylcholinesterase Inhibitor Bis(7)-tacrine, but Not Donepezil, Prevents Glutamate-induced Neuronal Apoptosis by Blocking N-Methyl-d-aspartate Receptors

Questioning the γ-gauche effect: stereoassignment of 1,3-disubstituted-tetrahydro-β-carbolines using 1H–1H coupling constants

Questioning the γ-gauche effect: stereoassignment of 1,3-disubstituted-tetrahydro-β-carbolines using 1 H- 1 H coupling constants

Bivalent Carbamates as Novel Control Agents of the Malaria Mosquito, Anopheles gambiae

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