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Building a Culture of Medicinal Chemistry Knowledge Sharing

Journal of medicinal chemistry, 2022-03, Vol.65 (5), p.3776-3785

2022

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Total Syntheses of (+)-Lyconadin A and (−)-Lyconadin B

Journal of the American Chemical Society, 2007-04, Vol.129 (14), p.4148-4149

2007

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MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate

ACS medicinal chemistry letters, 2018-07, Vol.9 (7), p.652-656

2018

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Microbial biotransformation - an important tool for the study of drug metabolism

Xenobiotica, 2019-08, Vol.49 (8), p.877-886

2019

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Novel M 1 allosteric ligands: a patent review

Expert opinion on therapeutic patents, 2012-12, Vol.22 (12), p.1385-1398

2012

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Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles

Journal of medicinal chemistry, 2017-08, Vol.60 (16), p.6771

2017

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The Lyconadins: Enantioselective Total Syntheses of (+)-Lyconadin A and (−)-Lyconadin B

Journal of the American Chemical Society, 2008-10, Vol.130 (41), p.13778-13789

2008

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Novel M1 allosteric ligands: a patent review

Expert opinion on therapeutic patents, 2012-12, Vol.22 (12), p.1385-1398

2012

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Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases

Communications biology, 2023-06, Vol.6 (1), p.649-649, Article 649

2023

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MK-7622: A First-in-Class M 1 Positive Allosteric Modulator Development Candidate

ACS medicinal chemistry letters, 2018-07, Vol.9 (7), p.652-656

2018

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Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction

ACS medicinal chemistry letters, 2021-04, Vol.12 (4), p.540-547

2021

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Design and Synthesis of Novel Isoquinoline-3-nitriles as Orally Bioavailable Kv1.5 Antagonists for the Treatment of Atrial Fibrillation

Journal of medicinal chemistry, 2006-11, Vol.49 (24), p.6954-6957

2006

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Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles: Miniperspective

Journal of medicinal chemistry, 2017-08, Vol.60 (16), p.6771-6780

2017

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2,5‐Disubstituted Pyrazolo[4,3‐c]cinnolin‐3‐ones

Journal of heterocyclic chemistry, 2017-03, Vol.54 (2), p.1558-1571

2017

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Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M1 positive allosteric modulators

Bioorganic & medicinal chemistry letters, 2014-03, Vol.24 (5), p.1417-1420

2014

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Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in dogs with underlying heart failure

The Journal of pharmacology and experimental therapeutics, 2008-01, Vol.324 (1), p.322

2008

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Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2493-2496

2010

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Hydroxy cycloalkyl fused pyridone carboxylic acid M1, positive allosteric modulators

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2538-2541

2010

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Preparation of Substituted Piperazinones via Tandem Reductive Amination−(N,N‘-Acyl Transfer)−Cyclization

Organic letters, 2002-04, Vol.4 (7), p.1201-1204

2002

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High-Throughput Agonist Shift Assay Development for the Analysis of M 1 -Positive Allosteric Modulators

SLAS discovery, 2017-09, Vol.22 (8), p.1060

2017

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Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation

Bioorganic & medicinal chemistry letters, 2020-07, Vol.30 (13), p.127197-127197, Article 127197

2020

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Recent advances in the synthesis of diketopiperazines

Tetrahedron, 2002-04, Vol.58 (17), p.3297-3312

2002

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Building a Culture of Medicinal Chemistry Knowledge Sharing

Total Syntheses of (+)-Lyconadin A and (−)-Lyconadin B

MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate

Microbial biotransformation - an important tool for the study of drug metabolism

A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV‑1 Infected Cells

Novel M 1 allosteric ligands: a patent review

Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles

The Lyconadins: Enantioselective Total Syntheses of (+)-Lyconadin A and (−)-Lyconadin B

Novel M1 allosteric ligands: a patent review

Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases

MK-7622: A First-in-Class M 1 Positive Allosteric Modulator Development Candidate

Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction

Design and Synthesis of Novel Isoquinoline-3-nitriles as Orally Bioavailable Kv1.5 Antagonists for the Treatment of Atrial Fibrillation

Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles: Miniperspective

2,5‐Disubstituted Pyrazolo[4,3‐c]cinnolin‐3‐ones

Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M1 positive allosteric modulators

Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in dogs with underlying heart failure

Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel

Hydroxy cycloalkyl fused pyridone carboxylic acid M1, positive allosteric modulators

Preparation of Substituted Piperazinones via Tandem Reductive Amination−(N,N‘-Acyl Transfer)−Cyclization

High-Throughput Agonist Shift Assay Development for the Analysis of M 1 -Positive Allosteric Modulators

3-Aminopyrrolidinone Farnesyltransferase Inhibitors: Design of Macrocyclic Compounds with Improved Pharmacokinetics and Excellent Cell Potency

Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation

Design and Biological Activity of (S)-4-(5-{[1-(3-Chlorobenzyl)-2- oxopyrrolidin-3-ylamino]methyl}imidazol-1-ylmethyl)benzonitrile, a 3-Aminopyrrolidinone Farnesyltransferase Inhibitor with Excellent Cell Potency

Recent advances in the synthesis of diketopiperazines

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